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The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: BMPG; Bone marrow proteoglycan; eosinophil major basic protein; LPR3; PRG-2; Proteoglycan 2
基因别名: Mbp; Prg2
UniProt ID: (Rat) Q63189
Entrez Gene ID: (Rat) 58826