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产品信息
PA5-28266
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 177 and 391 of Human PKA 2 beta
偶联物
形式
Liquid
浓度
0.67 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2545742
产品详细信息
Recommended positive controls: HeLa, HepG2, mouse brain, rat brain.
Predicted reactivity: Mouse (97%), Rat (96%), Xenopus laevis (84%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: cAMP-dependent protein kinase type II-beta regulatory chain; cAMP-dependent protein kinase type II-beta regulatory subunit; H_RG363E19.2; protein kinase, cAMP-dependent, regulatory subunit type II beta; protein kinase, cAMP-dependent, regulatory, type II, beta; Type II beta regulatory subunit of cAMP-dependent protein kinase; WUGSC:H_RG363E19.2
基因别名: AI451071; AW061005; Pkarb2; PKARIIbeta; PRKAR2; PRKAR2B; RATDNA; RII(beta); RII-BETA
UniProt ID: (Human) P31323, (Mouse) P31324, (Rat) P12369
Entrez Gene ID: (Human) 5577, (Mouse) 19088, (Rat) 24679
cAMP-dependent protein kinase inhibitor activity
protein binding
cAMP-dependent protein kinase regulator activity
protein domain specific binding
cAMP binding
ubiquitin protein ligase binding
protein kinase A catalytic subunit binding
nucleotide binding
protein kinase binding
protein-binding activity modulator
kinase modulator
G2/M transition of mitotic cell cycle
renal water homeostasis
fatty acid metabolic process
blood coagulation
learning
activation of protein kinase A activity
intracellular signal transduction
cellular response to glucagon stimulus
response to antipsychotic drug
response to clozapine
negative regulation of cAMP-dependent protein kinase activity
regulation of protein phosphorylation
regulation of protein kinase activity
