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产品信息
H00005587-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PRKD1 (AAI60015.1, 1 a.a. approximately 912 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MSAPPVLRPP SPLLPVAAAA AAAAAALVPG SGPGPAPFLA PVAAPVGGIS FHLQIGLSRE PVLLLQDSSG DYSLAHVREM ACSIVDQKFP ECGFYGMYDK ILLFRHDPTS ENILQLVKAA SDIQEGDLIE VVLSASATFE DFQIRPHALF VHSYRAPAFC DHCGEMLWGL VRQGLKCEGC GLNYHKRCAF KIPNNCSGVR RRRLSNVSLT GVSTIRTSSA ELSTSAPDEP LLQKSPSESF IGREKRSNSQ SYIGRPIHLD KILMSKVKVP HTFVIHSYTR PTVCQYCKKL LKGLFRQGLQ CKDCRFNCHK RCAPKVPNNC LGEVTINGDL LSPGAESDVV MEEGSDDNDS ERNSGLMDDM EEAMVQDAEM AMAECQNDSG EMQDPDPDHE DANRTISPST SNNIPLMRVV QSVKHTKRKS STVMKEGWMV HYTSKDTLRK RHYWRLDSKC ITLFQNDTGS RYYKEIPLSE ILSLEPVKTS ALIPNGANPH CFEITTANVV YYVGENVVNP SSPSPNNSVL TSGVGADVAR MWEIAIQHAL MPVIPKGSSV GTGTNLHRDI SVSISVSNCQ IQENVDISTV YQIFPDEVLG SGQFGIVYGG KHRKTGRDVA IKIIDKLRFP TKQESQLRNE VAILQNLHHP GVVNLECMFE TPERVFVVME KLHGDMLEMI LSSEKGRLPE HITKFLITQI LVALRHLHFK NIVHCDLKPE NVLLASADPF PQVKLCDFGF ARIIGEKSFR RSVVGTPAYL APEVLRNKGY NRSLDMWSVG VIIYVSLSGT FPFNEDEDIH DQIQNAAFMY PPNPWKEISH EAIDLINNLL QVKMRKRYSV DKTLSHPWLQ DYQTWLDLRE LECKIGERYI THESDDLRWE KYAGEQGLQY PTHLINPSAS HSDTPETEET EMKALGERVS IL
靶标信息
The PKC family of serine/threonine kinases, including PRKCN (PKD3), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. PKC mu activation is dependent on the phosphorylation of two activation loop sites, Ser744 and Ser748, via a PKC-dependent signaling pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZP586E0820; nPKC-D1; nPKC-D2; nPKC-mu; nPKC-nu; PKC mu; PKC nu; PKC u; PKC v; PKC-u; PKC-v; PKCmu; PKCu; PKCv; Protein kinase C mu type; Protein kinase C nu type; protein kinase C, mu; Protein kinase D; Protein kinase EPK2; Serine/threonine-protein kinase D1; Serine/threonine-protein kinase D2; Serine/threonine-protein kinase D3
基因别名: EPK2; HSPC187; nPKC-D2; nPKC-NU; PKC-MU; PKC-NU; PKCM; PKD; PKD1; PKD2; PKD3; PRKCM; PRKCN; PRKD1; PRKD2; PRKD3
UniProt ID: (Human) Q15139, (Human) Q9BZL6, (Human) O94806
Entrez Gene ID: (Human) 5587, (Human) 25865, (Human) 23683
angiogenesis
positive regulation of endothelial cell proliferation
protein phosphorylation
apoptotic process
inflammatory response
Golgi organization
signal transduction
integrin-mediated signaling pathway
Ras protein signal transduction
cell proliferation
positive regulation of endothelial cell migration
regulation of keratinocyte proliferation
positive regulation of neuron projection development
peptidyl-serine phosphorylation
sphingolipid biosynthetic process
regulation of protein stability
positive regulation of CREB transcription factor activity
positive regulation of peptidyl-serine phosphorylation
cellular response to oxidative stress
intracellular signal transduction
cellular response to vascular endothelial growth factor stimulus
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of blood vessel endothelial cell migration
innate immune response
positive regulation of osteoblast differentiation
positive regulation of angiogenesis
negative regulation of endocytosis
positive regulation of transcription from RNA polymerase II promoter
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
Golgi vesicle transport
positive regulation of NF-kappaB transcription factor activity
regulation of release of sequestered calcium ion into cytosol
negative regulation of cell death
protein kinase D signaling
positive regulation of histone deacetylase activity
positive regulation of endothelial cell chemotaxis
regulation of integrin-mediated signaling pathway
adaptive immune response
cell adhesion
cell death
positive regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of interleukin-2 production
positive regulation of interleukin-8 production
positive regulation of fibroblast growth factor receptor signaling pathway
positive regulation of cell adhesion
T cell receptor signaling pathway
positive regulation of T cell receptor signaling pathway
positive regulation of sequence-specific DNA binding transcription factor activity
endothelial tube morphogenesis
positive regulation of ERK1 and ERK2 cascade
mitophagy in response to mitochondrial depolarization
positive regulation of intracellular signal transduction
positive regulation of DNA biosynthetic process
protein kinase C-activating G-protein coupled receptor signaling pathway
