Invitrogen

PRKD2 Polyclonal Antibody

查看其他21个PRKD2抗体

抗体检测数据 (2)

PRKD2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PRKD2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PRKD2 Antibody (PA5-86295) in IHC (P)

Immunohistochemical analysis of PKD2 in paraffin-embedded human breast carcinoma tissue showing cytoplasm/cell membrane staining and negative control (right). Sample was incubated with polyclonal PKD2 antibody (Product # PA5-86295) using a 1:50 dilution, and followed by goat anti-rabbit IgG-biotin and avidin-peroxidase secondary antibodies.

PRKD2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PRKD2 Antibody in Western Blot (WB)

Product Image Gallery

PRKD2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of PKD2 in paraffin-embedded human breast carcinoma tissue showing cytoplasm/cell membrane staining and negative control (right). Sample was incubated with polyclonal PKD2 antibody (Product # PA5-86295) using a 1:50 dilution, and followed by goat anti-rabbit IgG-biotin and avidin-peroxidase secondary antibodies.

PRKD2 Antibody in Western Blot (WB) — Western blot analysis of PKD2 in Lane 1: HepG2 whole cell lysate (40 µg), Lane 2: Lung tissue lysate of mouse (40 µg), Lane 3: HCC827 whole cell lysate (40 µg), Lane 4: L02 whole cell lysate (40 µg). Sample was incubated with PKD2 polyclonal antibody (Product # PA5-86295) using a 1:500 dilution.

产品信息

PA5-86295

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

-

免疫组化（石蜡） (IHC (P))

1:50-1:200

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide, corresponding to amino acids 830-878 of Human PKD2.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 50% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2803079

产品详细信息

Purity is > 95% by SDS-PAGE.

靶标信息

PRKD2 (PKD2) is a member of the protein kinase D serine/threonine protein kinase family. PRKD2 is a component in the signal transduction pathway induced by phorbol esters and the CCK b gastrin receptor. It exhibits the strongest homology to the serine threonine protein kinases PKD/PKC and PKCnu, particularly in the duplex zinc finger-like cysteine-rich motif, in the pleckstrin homology domain and in the protein kinase domain. In contrast, it shows only a low degree of sequence similarity to other members of the PKC family.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: nPKC-D2; Serine/threonine-protein kinase D2

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基因别名: AI325941; HSPC187; nPKC-D2; PKD2; PRKD2; RGD1308054

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UniProt ID: (Human) Q9BZL6, (Rat) Q5XIS9, (Mouse) Q8BZ03

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Entrez Gene ID: (Human) 25865, (Rat) 292658, (Mouse) 101540

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protein kinase activity protein serine/threonine kinase activity protein kinase C activity protein binding ATP binding metal ion binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase

angiogenesis positive regulation of endothelial cell proliferation adaptive immune response protein phosphorylation cell adhesion cell death positive regulation of endothelial cell migration peptidyl-serine phosphorylation positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of interleukin-2 production positive regulation of interleukin-8 production positive regulation of CREB transcription factor activity positive regulation of peptidyl-serine phosphorylation intracellular signal transduction cellular response to vascular endothelial growth factor stimulus positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway positive regulation of blood vessel endothelial cell migration positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of angiogenesis positive regulation of cell adhesion positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation vascular endothelial growth factor receptor signaling pathway T cell receptor signaling pathway positive regulation of T cell receptor signaling pathway positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity endothelial tube morphogenesis positive regulation of ERK1 and ERK2 cascade protein kinase D signaling mitophagy in response to mitochondrial depolarization positive regulation of histone deacetylase activity positive regulation of intracellular signal transduction positive regulation of DNA biosynthetic process positive regulation of endothelial cell chemotaxis immune system process phosphorylation