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PRL1 Antibody (PA5-106431) in ICC/IF
Immunofluorescent analysis of PRL1 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and PRL1 polyclonal antibody (Product # PA5-106431) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
产品信息
PA5-106431
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PTP4A1(Accession Q93096), corresponding to amino acid residues N142-Q173.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2854103
产品详细信息
Antibody detects endogenous levels of total PTP4A1/PRL1.
靶标信息
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells. PRL phosphatases increase cell proliferation by stimulating progression from G1 into S phase. PRL-1 function is regulated in a cell cycle-dependent manner and implicate PRL-1 in regulating progression through mitosis, possibly by modulating spindle dynamics.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp779M0721; PRL-1; protein tyrosine phosphatase 4a1; Protein tyrosine phosphatase type IVA 1; protein tyrosine phosphatase type IVA protein 1; Protein-tyrosine phosphatase 4a1; Protein-tyrosine phosphatase of regenerating liver 1; PTP(CAAXI); PTP4A1 protein; PTP4A2; RP5-1148A21.2
基因别名: AA415290; AU019864; C130021B01; HH72; PRL-1; PRL1; PTP(CAAX1); PTP4A1; PTPCAAX1
UniProt ID: (Human) Q93096, (Rat) Q78EG7, (Mouse) Q63739
Entrez Gene ID: (Human) 7803, (Rat) 29463, (Mouse) 19243
