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产品信息
PA5-142908
产品规格
种属反应
Human,
Mouse,
Pig,
Rat
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence C-DQPRTTKYHSVILQ.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2933551
产品详细信息
Additional Information: This antibody is expected to recognize all reported isoforms (NP_001526.2; NP_001229793.1; NP_001229794.1; NP_001229795.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
靶标信息
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Histone-arginine N-methyltransferase PRMT2; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1; HMT1 hnRNP methyltransferase-like 1; MGC111373; PRMT2 alpha; PRMT2 beta; PRMT2 gamma; Protein arginine N-methyltransferase 2
基因别名: AI504737; HMT1; HRMT1L1; PRMT2
UniProt ID: (Human) P55345
Entrez Gene ID: (Human) 3275, (Pig) 100294709, (Mouse) 15468, (Rat) 499420
transcription coactivator activity
signal transducer activity
protein binding
histone-arginine N-methyltransferase activity
protein-arginine N-methyltransferase activity
estrogen receptor binding
progesterone receptor binding
protein-arginine omega-N asymmetric methyltransferase activity
histone methyltransferase activity
protein homodimerization activity
retinoic acid receptor binding
peroxisome proliferator activated receptor binding
thyroid hormone receptor binding
androgen receptor binding
molecular_function
cytokine activity
tumor necrosis factor receptor binding
beta-catenin binding
protein modifying enzyme
protein methylation
signal transduction
histone methylation
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
negative regulation of NF-kappaB transcription factor activity
histone arginine methylation
positive regulation of apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
developmental cell growth
regulation of androgen receptor signaling pathway
negative regulation of G1/S transition of mitotic cell cycle
response to hypoxia
immune response
biological_process
peptidyl-arginine N-methylation
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of extrinsic apoptotic signaling pathway
