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PROP1 Antibody (PA5-116708) in WB
Western blot analysis of PROP1 in mouse brain. Samples were incubated with PROP1 Polyclonal antibody (Product # PA5-116708) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 50s.
产品信息
PA5-116708
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PROP1 (NP_0062523)
偶联物
形式
Liquid
浓度
0.89 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2901339
产品详细信息
Positive Samples: Mouse brain
Immunogen sequence: GGGRSRFSPQ GGQRGRPHSR RRHRTTFSPV QLEQLESAFG RNQYPDIWAR ESLARDTGLS EARIQVWFQN RRAKQRKQER SLLQPLAHLS PAAFSSFLPE S
靶标信息
PROP1 encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ames dwarf; Homeobox protein prophet of Pit-1; pituitary specific homeodomain factor; Pituitary-specific homeodomain factor; PROP-1; prophet of Pit-1
基因别名: df; Prop-1; Prop1
UniProt ID: (Mouse) P97458
Entrez Gene ID: (Mouse) 19127
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
DNA binding
chromatin binding
protein binding
beta-catenin binding
protein C-terminus binding
sequence-specific DNA binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
blood vessel development
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
organ morphogenesis
dorsal/ventral pattern formation
cell migration
hypothalamus cell differentiation
adenohypophysis development
negative regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
gland development
hypophysis morphogenesis
canonical Wnt signaling pathway
somatotropin secreting cell differentiation
