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PRRX2 Antibody (PA5-103995) in IHC (P)
Immunohistochemistry analysis of PRRX2 in human pancreatic cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with PRRX2 polyclonal antibody (Product # PA5-103995) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-103995
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PRRX2(Accession Q99811), corresponding to amino acid residues A65-Q115.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2853326
产品详细信息
Antibody detects endogenous levels of total PRRX2.
靶标信息
The paired-class homeobox genes PRX1 and PRX2 are necessary for craniofacial and limb development and are expressed in similar patterns in the cranial mesenchyme, limb buds, axial mesoderm and branchial arches. These proteins exhibit different patterns of expression, however, in heart and brain tissue. Specifically, PRX1 is expressed in the endocardial cusions, semilunar and atrioventricular valves, whereas PRX2 is initially expressed in a diffuse myocardial pattern and is later expressed in the ventricular septum. Furthermore, PRX2 is never expressed in the brain, whereas PRX1 is expressed in the ventral hypothalamus and in the telencephalon. Murine mutants lacking PRX1 function demonstrate skeletal defects in the skull, limbs, and vertebral column. Mice lacking functional PRX2 alone do not demonstrate skeletal abnormalities, however, PRX1/PRX2 double mutants demonstrate novel abnormalities that are not visualized with the PRX1-deficient mice. Transcripts of neither PRX1 nor PRX2 are detected in normal adult rat pulmonary arteries, however vascular disease induces PRX gene expression wherein they co-localize to sites of Tenascin-C expression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: homeo box of paired rule; Homeobox protein S8; MGC19843; Paired mesoderm homeobox protein 2; paired-like homeodomain protein PRX2; Paired-related homeobox protein 2; PRX-2; surface antigen, homeo box of paired rule; testicular tissue protein Li 148; testicular tissue protein Li 160
基因别名: PMX2; PRRX2; PRX2; S8
UniProt ID: (Human) Q99811, (Mouse) Q06348
Entrez Gene ID: (Human) 51450, (Mouse) 20204, (Rat) 113931
positive regulation of mesenchymal cell proliferation
regulation of transcription, DNA-templated
multicellular organism development
embryonic limb morphogenesis
inner ear morphogenesis
middle ear morphogenesis
positive regulation of smoothened signaling pathway
embryonic cranial skeleton morphogenesis
embryonic skeletal system morphogenesis
artery morphogenesis
cartilage development
