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产品信息
PA5-102490
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PSAP(Accession P07602), corresponding to amino acid residues E306-E356.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2851892
产品详细信息
Antibody detects endogenous levels of total PSAP.
靶标信息
PSAP is a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Proactivator polypeptide; Prosaposin; prosaposin (sulfated glycoprotein, sphingolipid hydrolase activator); SGP-1; snoRNA MBII-198; sphingolipid activator protein-1; Sulfated glycoprotein 1
基因别名: AI037048; GLBA; PSAP; SAP1; SGP-1; Sgp1; SGP1A
UniProt ID: (Human) P07602, (Rat) P10960, (Mouse) Q61207
Entrez Gene ID: (Human) 5660, (Rat) 25524, (Mouse) 19156
platelet degranulation
glycosphingolipid metabolic process
lipid transport
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
regulation of autophagy
regulation of lipid metabolic process
positive regulation of catalytic activity
positive regulation of MAPK cascade
prostate gland growth
epithelial cell differentiation involved in prostate gland development
cellular response to organic substance
negative regulation of hydrogen peroxide-induced cell death
sphingolipid metabolic process
regulation of MAPK cascade
glycolipid transport
developmental growth
lipid metabolic process
