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MA5-17159 targets PSAP in indirect ELISA, FACS, ICC, IHC, IF and WB applications and shows reactivity with Human samples.
The MA5-17159 immunogen is purified recombinant fragment of human PSAP (amino acids: 325-524 ) expressed in E. Coli.
MA5-17159 detects PSAP which has a predicted molecular weight of approximately 58.1kDa.
PSAP is a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Proactivator polypeptide; Prosaposin; sphingolipid activator protein-1
基因别名: GLBA; PSAP; SAP1
UniProt ID: (Human) P07602
Entrez Gene ID: (Human) 5660