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PA1-1960 detects proteasome 20S LMP2 from human and mouse cells.
PA1-1960 can be successfully used in Western blot procedures. By Western blot this antibody detects an ~23 kDa protein representing proteasome 20S LMP2 from mouse embryo fibroblast cell extract. This antibody also recognizes a band at ~24 kDa, which may correspond to LMP2 precursor protein.
The PA1-1960 immunogen is a mixture of synthetic peptides corresponding to residues C R(207) V I L G N/D E L P K F Y D E(220) of human and mouse proteasome 20S LMP2. These peptides are available for use in neutralization and control procedures.
PA1-1960 can be used with blocking peptide PEP-176.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC in the immunoproteasome. Proteolytic processing is required to generate a mature subunit.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: large multifunctional peptidase 2; large multifunctional protease 2; LMP-2d; Low molecular mass protein 2; Macropain chain 7; MGC70470; Multicatalytic endopeptidase complex chain 7; proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2); proteasome catalytic subunit 1i; Proteasome chain 7; proteasome subunit beta 6i; proteasome subunit beta type 9; Proteasome subunit beta type-9; Proteasome subunit beta-1i; proteasome-related gene 2; proteosome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2); proteosome beta 9 subunit; Really interesting new gene 12 protein
基因别名: beta1i; Lmp-2; LMP2; PSMB6i; PSMB9; RING12
UniProt ID: (Human) P28065, (Mouse) P28076
Entrez Gene ID: (Human) 5698, (Mouse) 16912