Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
PA1-23381
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues K(269) K I N Y Q V D S W E(279) of mouse PTCH.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2253264
产品详细信息
This antibody is expected to cross-react with rat, chicken, and human due to 100% sequence homology.
靶标信息
This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: etID309849.2; FLJ26746; FLJ42602; HGNC:9585; mesenchymal dysplasia; OTTHUMP00000021709; OTTHUMP00000021710; patched; Patched 1; patched1; Protein patched homolog 1; PTC; ptc-1; PTCH protein -3; Ptch1 protein +12b; RP11-435O5.3
基因别名: A230106A15Rik; mes; Ptc; Ptc1; Ptch; Ptch1
UniProt ID: (Mouse) Q61115
Entrez Gene ID: (Mouse) 19206
negative regulation of transcription from RNA polymerase II promoter
branching involved in ureteric bud morphogenesis
in utero embryonic development
cell fate determination
neural tube formation
neural tube closure
heart morphogenesis
signal transduction
smoothened signaling pathway
regulation of mitotic cell cycle
pattern specification process
brain development
negative regulation of cell proliferation
epidermis development
regulation of smoothened signaling pathway
organ morphogenesis
dorsal/ventral pattern formation
epidermal cell fate specification
response to chlorate
positive regulation of cholesterol efflux
protein processing
spinal cord motor neuron differentiation
neural tube patterning
dorsal/ventral neural tube patterning
neural plate axis specification
embryonic limb morphogenesis
mammary gland development
regulation of protein localization
limb morphogenesis
hindlimb morphogenesis
regulation of growth
negative regulation of multicellular organism growth
regulation of cell proliferation
glucose homeostasis
negative regulation of sequence-specific DNA binding transcription factor activity
keratinocyte proliferation
positive regulation of epidermal cell differentiation
negative regulation of osteoblast differentiation
negative regulation of smoothened signaling pathway
embryonic organ development
negative regulation of epithelial cell proliferation
negative regulation of cell division
pharyngeal system development
mammary gland duct morphogenesis
mammary gland epithelial cell differentiation
smoothened signaling pathway involved in dorsal/ventral neural tube patterning
cell differentiation involved in kidney development
somite development
cellular response to cholesterol
cell proliferation involved in metanephros development
protein targeting to plasma membrane
