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产品信息
PA1-4134
产品规格
种属反应
Chicken,
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues K(269) K I N Y Q V D S W E(279) of mouse PTCH.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2174042
产品详细信息
PA1-4134 detects Patched (PTCH) in human samples.
PA1-4134 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~158 kDa protein representing PTCH in fetal brain lysate.
The PA1-4134 immunogen is a synthetic peptide corresponding to residues K(269) K I N Y Q V D S W E(279) of mouse PTCH. This sequence is 100% conserved in human, rat, and chicken PTCH, and is expected to cross react with these samples.
靶标信息
This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: etID309849.2; FLJ26746; FLJ42602; HGNC:9585; mesenchymal dysplasia; OTTHUMP00000021709; OTTHUMP00000021710; patched; Patched 1; patched homolog 1; patched homolog 2; patched protein; patched-like protein; patched1; Protein patched homolog 1; PTC; ptc-1; PTC1; PTCH protein +12b; PTCH protein +4'; PTCH protein -10; PTCH protein -3; PTCH protein -3,4,5; Ptch1 protein +12b; RP11-435O5.3
基因别名: A230106A15Rik; BCNS; HPE7; mes; NBCCS; PTC; PTC1; PTCH; PTCH1; PTCH11; Ptch2
UniProt ID: (Human) Q5VZC2, (Mouse) Q61115
Entrez Gene ID: (Human) 5727, (Chicken) 395806, (Rat) 89830, (Mouse) 19206
negative regulation of transcription from RNA polymerase II promoter
branching involved in ureteric bud morphogenesis
in utero embryonic development
cell fate determination
neural tube formation
neural tube closure
heart morphogenesis
signal transduction
smoothened signaling pathway
regulation of mitotic cell cycle
pattern specification process
brain development
negative regulation of cell proliferation
epidermis development
regulation of smoothened signaling pathway
response to mechanical stimulus
organ morphogenesis
dorsal/ventral pattern formation
epidermal cell fate specification
response to chlorate
positive regulation of cholesterol efflux
response to organic cyclic compound
protein processing
spinal cord motor neuron differentiation
neural tube patterning
dorsal/ventral neural tube patterning
neural plate axis specification
embryonic limb morphogenesis
mammary gland development
response to estradiol
response to retinoic acid
regulation of protein localization
limb morphogenesis
hindlimb morphogenesis
regulation of growth
negative regulation of multicellular organism growth
regulation of cell proliferation
response to drug
glucose homeostasis
negative regulation of sequence-specific DNA binding transcription factor activity
keratinocyte proliferation
positive regulation of epidermal cell differentiation
negative regulation of osteoblast differentiation
negative regulation of smoothened signaling pathway
embryonic organ development
negative regulation of epithelial cell proliferation
negative regulation of cell division
pharyngeal system development
mammary gland duct morphogenesis
mammary gland epithelial cell differentiation
smoothened signaling pathway involved in dorsal/ventral neural tube patterning
cell differentiation involved in kidney development
somite development
cellular response to cholesterol
renal system development
cell proliferation involved in metanephros development
protein targeting to plasma membrane
positive regulation of transcription, DNA-templated
