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产品信息
PA5-28712
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to a region within amino acids 1381 and 1447 of Patched 1
偶联物
形式
Liquid
浓度
0.85 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2546188
产品详细信息
Recommended positive controls: A431, H1299, HeLa, HepG2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: etID309849.2; FLJ26746; FLJ42602; HGNC:9585; OTTHUMP00000021709; OTTHUMP00000021710; patched; patched1; Protein patched homolog 1; PTC; ptc-1; PTCH protein +12b; PTCH protein +4'; PTCH protein -10; PTCH protein -3; PTCH protein -3,4,5; RP11-435O5.3
基因别名: BCNS; HPE7; NBCCS; PTC; PTC1; PTCH; PTCH1; PTCH11
UniProt ID: (Human) Q13635
Entrez Gene ID: (Human) 5727
negative regulation of transcription from RNA polymerase II promoter
branching involved in ureteric bud morphogenesis
in utero embryonic development
cell fate determination
neural tube closure
heart morphogenesis
smoothened signaling pathway
regulation of mitotic cell cycle
brain development
regulation of smoothened signaling pathway
response to mechanical stimulus
organ morphogenesis
dorsal/ventral pattern formation
epidermal cell fate specification
response to chlorate
positive regulation of cholesterol efflux
protein processing
spinal cord motor neuron differentiation
neural tube patterning
neural plate axis specification
embryonic limb morphogenesis
response to estradiol
response to retinoic acid
regulation of protein localization
limb morphogenesis
hindlimb morphogenesis
negative regulation of multicellular organism growth
response to drug
glucose homeostasis
negative regulation of sequence-specific DNA binding transcription factor activity
keratinocyte proliferation
positive regulation of epidermal cell differentiation
negative regulation of osteoblast differentiation
negative regulation of smoothened signaling pathway
positive regulation of transcription, DNA-templated
embryonic organ development
negative regulation of epithelial cell proliferation
negative regulation of cell division
pharyngeal system development
mammary gland duct morphogenesis
mammary gland epithelial cell differentiation
smoothened signaling pathway involved in dorsal/ventral neural tube patterning
cell differentiation involved in kidney development
somite development
cellular response to cholesterol
renal system development
cell proliferation involved in metanephros development
protein targeting to plasma membrane
