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产品信息
PA5-112677
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Pancreas transcription factor 1 subunit alpha protein (224-325AA)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_2867412
靶标信息
PFT1A is a component of the pancreas transcription factor 1 complex and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bHLH transcription factor p48; bHLHa29; Class A basic helix-loop-helix protein 29; class II bHLH protein PTF1A; exocrine pancreas-specific transcription factor p48; p48 DNA-binding subunit of transcription factor PTF1; Pancreas transcription factor 1 subunit alpha; pancreas transcription factor1 p48 subunit; Pancreas-specific transcription factor 1a; PTF1-p48
基因别名: BHLHA29; PACA; PAGEN2; PTF1-p48; PTF1A; PTF1P48
UniProt ID: (Human) Q7RTS3, (Rat) Q64305, (Mouse) Q9QX98
Entrez Gene ID: (Human) 256297, (Rat) 117034, (Mouse) 19213
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
chromatin binding
protein dimerization activity
E-box binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
protein binding
basic helix-loop-helix transcription factor
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
embryo development
tissue development
retina layer formation
cerebellum development
pancreas development
exocrine pancreas development
amacrine cell differentiation
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
neuron fate commitment
regulation of neural retina development
transcription, DNA-templated
cell differentiation
hindbrain development
cell fate commitment
positive regulation of transcription, DNA-templated
generation of neurons
retina morphogenesis in camera-type eye
multicellular organism development
nervous system development
