Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
H00005747-B01P
产品规格
种属反应
Human,
Rat
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PTK2 (AAH28733.1, 1 a.a. approximately 680 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5-1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MKYQEVRCLT SFNISVSFPA ETDDYAEIID EEDTYTMPST RDYEIQRERI ELGRCIGEGQ FGDVHQGIYM SPENPALAVA IKTCKNCTSD SVREKFLQEA LTMRQFDHPH IVKLIGVITE NPVWIIMELC TLGELRSFLQ VRKYSLDLAS LILYAYQLST ALAYLESKRF VHRDIAARNV LVSSNDCVKL GDFGLSRYME DSTYYKASKG KLPIKWMAPE SINFRRFTSA SDVWMFGVCM WEILMHGVKP FQGVKNNDVI GRIENGERLP MPPNCPPTLY SLMTKCWAYD PSRRPRFTEL KAQLSTILEE EKAQQEERMR MESRRQATVS WDSGGSDEAP PKPSRPGYPS PRSSEGFYPS PQHMVQTNHY QVSGYPGSHG ITAMAGSIYP GQASLLDQTD SWNHRPQEIA MWQPNVEDST VLDLRGIGQV LPTHLMEERL IRQQQEMEED QRWLEKEERF LKPDVRLSRG SIDREDGSLQ GPIGNQHIYQ PVGKPDPAAP PKKPPRPGAP GHLGSLASLS SPADSYNEGV KLKPQEISPP PTANLDRSND KVYENVTGLV KAVIEMSSKI QPAPPEEYVP MVKEVGLALR TLLATVDETI PLLPASTHRE IEMAQKLLNS DLGELINKMK LAQQYVMTSL QQEYKKQMLT AAHALAVDAK NLLDVIDQAR LKMLGQTRRH
靶标信息
Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor protein tyrosine kinase that acts as a substrate for Src and is a key element of integrin signaling. FAK plays an important role in cell spreading, differentiation, migration, cell death, and acceleration of the G1 to S phase transition of the cell cycle. FAK has a central catalytic domain and a C-terminal tail that localizes it to focal adhesions, which are sites where cells attach to the extracellular matrix via surface integrin receptors. Increased FAK tyrosine phosphorylation occurs upon integrin engagement with fibronectin. Adhesion of murine NIH3T3 fibroblasts to fibronectin promotes association of the Grb2 adapter protein and c-Src PTK with FAK in vivo, and also results in activation of the ERK2 MAP kinase. In v-Src-transformed NIH3T3, the association of v-Src, Grb2, and Sos with FAK is independent of cell adhesion to fibronectin. In vitro the Grb2 SH2 domain binds directly to tyrosine-phosphorylated FAK, and the binding site has been identified as Tyr925 by site directed mutagenesis. Several transcript variants encoding different isoforms have been found for the FAK gene, but the full-length natures of only three of them have been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: EC 2.7.10.2; FADK 1; FAK-related non-kinase polypeptide; Focal adhesion kinase 1; focal adhesion kinase isoform FAK-Del33; Focal adhesion kinase-related nonkinase; FRNK; p125FAK; pp125 PTK2; pp125FAK; PPP1R71; Protein phosphatase 1 regulatory subunit 71; protein phosphatase 1, regulatory subunit 71; Protein-tyrosine kinase 2; PTK2 protein tyrosine kinase 2
基因别名: FADK; FAK; FAK1; FRNK; p125FAK; pp125FAK; PPP1R71; PTK2
UniProt ID: (Human) Q05397, (Rat) O35346
Entrez Gene ID: (Human) 5747, (Rat) 25614
actin binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
signal transducer activity
Ras guanyl-nucleotide exchange factor activity
receptor binding
protein binding
ATP binding
JUN kinase binding
protein kinase binding
SH2 domain binding
integrin binding
protein complex binding
identical protein binding
phosphatidylinositol 3-kinase binding
MAPK cascade
microtubule cytoskeleton organization
angiogenesis
vasculogenesis
neuron migration
placenta development
regulation of protein phosphorylation
positive regulation of protein phosphorylation
heart morphogenesis
cellular component disassembly involved in execution phase of apoptosis
signal complex assembly
epidermal growth factor receptor signaling pathway
transforming growth factor beta receptor signaling pathway
integrin-mediated signaling pathway
axon guidance
positive regulation of cell proliferation
regulation of cell shape
embryo development
regulation of endothelial cell migration
regulation of epithelial cell migration
positive regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
central nervous system neuron axonogenesis
negative regulation of cell-cell adhesion
establishment of cell polarity
extracellular matrix organization
positive regulation of cell migration
regulation of cell adhesion mediated by integrin
netrin-activated signaling pathway
peptidyl-tyrosine autophosphorylation
Fc-gamma receptor signaling pathway involved in phagocytosis
establishment of nucleus localization
regulation of cell proliferation
negative regulation of apoptotic process
regulation of GTPase activity
endothelial cell migration
positive regulation of GTPase activity
positive regulation of phosphatidylinositol 3-kinase activity
innate immune response
regulation of osteoblast differentiation
positive regulation of protein kinase activity
negative regulation of organ growth
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
ephrin receptor signaling pathway
cell motility
negative regulation of axonogenesis
regulation of cytoskeleton organization
regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
negative regulation of synapse assembly
growth hormone receptor signaling pathway
regulation of substrate adhesion-dependent cell spreading
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of anoikis
blood vessel development
cytoskeleton organization
JNK cascade
response to mechanical stimulus
response to glucose
response to organic substance
response to organonitrogen compound
response to organic cyclic compound
positive regulation of smooth muscle cell migration
positive regulation of cell growth
negative regulation of cell migration
cellular chloride ion homeostasis
response to estradiol
response to drug
fat cell differentiation
positive regulation of cell adhesion
positive regulation of vasodilation
response to arsenic-containing substance
positive regulation of smooth muscle cell proliferation
positive regulation of phagocytosis
positive regulation of synaptic transmission
positive regulation of glial cell proliferation
cellular response to transforming growth factor beta stimulus
