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产品信息
PA5-20424
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
An 18 amino acid peptide from near the carboxy terminus of human PTK7.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11153267
产品详细信息
A suggested positive control is human colon tissue lysate.
PA5-20424 can be used with blocking peptide PEP-0541.
靶标信息
CCK4 may function as a cell adhesion molecule. Although it belongs to the insulin receptor subfamily of the Tyr protein kinases, it likely lacks the catalytic activity of a tyrosine kinase. It may be connected to the pathophysiology of colon carcinomas and/or may represent a tumor progression marker. This Type I membrane protein is highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes, but weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle, and not in colon. It is also expressed in erythroleukemia cells.
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生物信息学
蛋白别名: CCK-4; Colon carcinoma kinase 4; Inactive tyrosine-protein kinase 7; Protein chuzhoi; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; PTK7 protein tyrosine kinase 7; receptor tyrosine kinase-like protein; serum response factor; Tyrosine-protein kinase-like 7
基因别名: 8430404F20Rik; CCK-4; CCK4; chz; mPTK7/CCK4; PTK7; Srf
UniProt ID: (Human) Q13308, (Mouse) Q8BKG3
Entrez Gene ID: (Human) 5754, (Rat) 301242, (Mouse) 71461
protein kinase activity
protein binding
ATP binding
coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
kinase activity
transferase activity, transferring phosphorus-containing groups
establishment of planar polarity
neural tube closure
axis elongation
protein phosphorylation
positive regulation of neuron projection development
cell migration
peptidyl-tyrosine phosphorylation
actin cytoskeleton reorganization
wound healing
establishment of epithelial cell apical/basal polarity
convergent extension
canonical Wnt signaling pathway
lung-associated mesenchyme development
cellular response to retinoic acid
cochlea morphogenesis
planar cell polarity pathway involved in neural tube closure
cell adhesion
Wnt signaling pathway
ventricular septum development
signal transduction
coronary vasculature development
