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PTPRK Antibody (PA5-104089) in IHC (P)
Immunohistochemistry analysis of PTPRK in mouse kidney tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with PTPRK polyclonal antibody (Product # PA5-104089) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-104089
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PTPRK(Accession Q15262), corresponding to amino acid residues S804-T854.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2853417
产品详细信息
Antibody detects endogenous levels of total PTPRK.
靶标信息
Protein tyrosine phosphatases, or PTPs, are type I transmembrane proteins, membrane associated proteins or proteins localized in nuclei. Examples of transmembrane PTPs are LAR, PTP alpha, PTP beta, PTP gamma, PTP delta, PTP epsilon, PTP zeta, PTPk and PTP-mu. Transmembrane PTPs play diverse roles during development and in adult tissues. Immunodepletion studies have suggested LAR to be a regulator of Insulin receptor phosphorylation. PTP alpha activity is increased twofold in response to phorbol ester stimulation, resulting in serine phosphorylation either directly or indirectly by members of the PKC family. Overexpression of v-H-ras and Neu, but not Myc or Int2, in mammary tumors has been shown to induce PTP epsilon expression. An alternative splicing event leads to a nervous tissue-specific chondroitin sulfate proteoglycan called phosphacan, which represents the amino terminal portion of PTP zeta. PTPk and PTP-mu share a conserved amino terminal 160 amino acid MAM domain which facilitates homophilic binding. PTP-mu localizes to points of cell contact and may be involved in regulating the assembly and disassembly of cadherin/catenin complexes in vivo.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: dJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappa; protein tyrosine phosphatase, receptor type, K; Protein-tyrosine phosphatase kappa; protein-tyrosine phosphatase, receptor type, kappa; R-PTP-k; R-PTP-kappa; R-PTPk; Receptor-type tyrosine-protein phosphatase kappa
基因别名: AI853699; PTPK; PTPRK; R-PTP-kappa; RPTPkappa
UniProt ID: (Human) Q15262, (Mouse) P35822
Entrez Gene ID: (Human) 5796, (Mouse) 19272
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity
protein binding
beta-catenin binding
protein kinase binding
gamma-catenin binding
phosphoprotein phosphatase activity
hydrolase activity
phosphatase activity
extracellular matrix glycoprotein
protein phosphatase
protein modifying enzyme
protein dephosphorylation
cell adhesion
signal transduction
transforming growth factor beta receptor signaling pathway
negative regulation of cell proliferation
negative regulation of keratinocyte proliferation
cell migration
negative regulation of cell migration
neuron projection development
protein localization to cell surface
cellular response to reactive oxygen species
cellular response to UV
peptidyl-tyrosine dephosphorylation
negative regulation of cell cycle
negative regulation of transcription, DNA-templated
focal adhesion assembly
dephosphorylation
