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产品信息
10076-MSM3-P1ABX
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2, kappa
分类
Monoclonal
类型
Antibody
克隆号
PTPRU/7616
抗原
Recombinant fragment (around aa1-200) of human PTPRU protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS
内含物
no preservative
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
Positive Control: colon or skeletal muscle. Human brain pancreas
Cellular Location: Cell junction. Cell membrane. Single-pass type I membrane protein.
靶标信息
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GLEPP1; Pancreatic carcinoma phosphatase 2; PCP-2; pi R-PTP-Psi; protein tyrosine phosphatase, receptor type, U; Protein-tyrosine phosphatase J; Protein-tyrosine phosphatase pi; Protein-tyrosine phosphatase receptor omicron; PTP pi; PTP-J; PTP-RO; R-PTP-psi; R-PTP-U; Receptor protein tyrosine phosphatase hPTP-J; Receptor-type protein-tyrosine phosphatase psi; Receptor-type tyrosine-protein phosphatase U
基因别名: FMI; hPTP-J; PCP-2; PCP2; PTP; PTP-J; PTP-PI; PTP-RO; PTPPSI; PTPRO; PTPRU; PTPU2; R-PTP-PSI; R-PTP-U
UniProt ID: (Human) Q92729
Entrez Gene ID: (Human) 10076
protein dephosphorylation
cell adhesion
transmembrane receptor protein tyrosine phosphatase signaling pathway
negative regulation of cell proliferation
single organismal cell-cell adhesion
cell differentiation
negative regulation of cell migration
organ regeneration
homotypic cell-cell adhesion
protein localization to cell surface
peptidyl-tyrosine dephosphorylation
response to glucocorticoid
canonical Wnt signaling pathway
