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Product Details
MA5-33376
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2C3
Immunogen
Recombinant mouse PTX3
Conjugate
Form
Liquid
Concentration
100 µg/mL
Purification
Protein G
Storage buffer
PBS with 0.1% BSA
Contains
no preservative
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2815514
Product Specific Information
Product is supplied at 1 mL (100 µL/mL).
Application Notes: Western blot- A non-reduced sample treatment and SDS-Page was used. The band size is 400 kDa. Flow cytometry - This antibody stains the intra and extracellular domain of Pentraxin 3. For intracellular staining cells were permeabilized with buffer containing triton. Transfected cells were used as a positive control.
Target Information
Pentraxins are a protein superfamily that is characterized by a cyclic multimeric structure. Ptx3, also known as tumor necrosis factor-stimulated gene sequence-14 (TSG14), is a secreted pattern-recognition receptor that has a non-redundant role in resistance to selected microbial agents. Ptx3 belongs to the family of "long pentraxins", which have C-terminal pentraxin domains and novel amino-terminal domains. Ptx3 binds selected pathogens, including Aspergillus fumigatus, Pseudomonas aeruginosa and Salmonella typhimurium. It is synthesized in IgA glomerulonephritis and activates mesangial cells. Secretion of Ptx3 in adipose cells can be induced by TNF. Ptx3 is also involved in amplification of inflammatory reactions and regulation of innate immunity. The human PTX3 gene maps to chromosome 3q25.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: pentaxin related; Pentaxin-related protein PTX3; pentraxin 3; Pentraxin-related protein PTX3; TSG-14; Tumor necrosis factor-inducible gene 14 protein
Gene Aliases: AI607804; Ptx3; TSG-14; Tsg14
UniProt ID: (Mouse) P48759
Entrez Gene ID: (Mouse) 19288
response to yeast
opsonization
negative regulation by host of viral exo-alpha-sialidase activity
negative regulation by host of viral glycoprotein metabolic process
innate immune response
positive regulation of nitric oxide biosynthetic process
negative regulation of viral entry into host cell
positive regulation of phagocytosis
negative regulation of exo-alpha-sialidase activity
negative regulation of glycoprotein metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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