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产品信息
MA5-33376
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
2C3
抗原
Recombinant mouse PTX3
偶联物
形式
Liquid
浓度
100 µg/mL
纯化类型
Protein G
保存液
PBS with 0.1% BSA
内含物
no preservative
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2815514
产品详细信息
Product is supplied at 1 mL (100 µL/mL).
Application Notes: Western blot- A non-reduced sample treatment and SDS-Page was used. The band size is 400 kDa. Flow cytometry - This antibody stains the intra and extracellular domain of Pentraxin 3. For intracellular staining cells were permeabilized with buffer containing triton. Transfected cells were used as a positive control.
靶标信息
Pentraxins are a protein superfamily that is characterized by a cyclic multimeric structure. Ptx3, also known as tumor necrosis factor-stimulated gene sequence-14 (TSG14), is a secreted pattern-recognition receptor that has a non-redundant role in resistance to selected microbial agents. Ptx3 belongs to the family of "long pentraxins", which have C-terminal pentraxin domains and novel amino-terminal domains. Ptx3 binds selected pathogens, including Aspergillus fumigatus, Pseudomonas aeruginosa and Salmonella typhimurium. It is synthesized in IgA glomerulonephritis and activates mesangial cells. Secretion of Ptx3 in adipose cells can be induced by TNF. Ptx3 is also involved in amplification of inflammatory reactions and regulation of innate immunity. The human PTX3 gene maps to chromosome 3q25.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: pentaxin related; Pentaxin-related protein PTX3; pentraxin 3; Pentraxin-related protein PTX3; TSG-14; Tumor necrosis factor-inducible gene 14 protein
基因别名: AI607804; Ptx3; TSG-14; Tsg14
UniProt ID: (Mouse) P48759
Entrez Gene ID: (Mouse) 19288
response to yeast
opsonization
negative regulation by host of viral exo-alpha-sialidase activity
negative regulation by host of viral glycoprotein metabolic process
innate immune response
positive regulation of nitric oxide biosynthetic process
negative regulation of viral entry into host cell
positive regulation of phagocytosis
negative regulation of exo-alpha-sialidase activity
negative regulation of glycoprotein metabolic process
