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PURA Antibody (PA5-115808) in IHC (P)
Immunohistochemistry analysis of PURA in rat brain tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115808) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
产品信息
PA5-115808
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PURA(Accession Q00577), corresponding to amino acid residues V106-Y156.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900442
产品详细信息
Antibody detects endogenous levels of total PURA.
靶标信息
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Pur alpha; pura {ECO:0000250|UniProtKB:P42669}; purine rich element binding protein A; purine-rich element binding protein A; Purine-rich single-stranded DNA-binding protein alpha; purine-rich single-stranded DNA-binding protein alpha {ECO:0000250|UniProtKB:P42669}; Transcriptional activator protein Pur-alpha; transcriptional activator protein Pur-alpha {ECO:0000250|UniProtKB:P42669}
基因别名: CAGER-1; MRD31; PUR-ALPHA; PUR1; PURA; PURALPHA; ssCRE-BP
UniProt ID: (Human) Q00577, (Mouse) P42669
Entrez Gene ID: (Human) 5813, (Mouse) 19290, (Rat) 307498
translation repressor activity, nucleic acid binding
double-stranded telomeric DNA binding
single-stranded DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
transcription factor binding
purine-rich negative regulatory element binding
poly(A) RNA binding
SMAD binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
DNA-binding transcription factor
DNA unwinding involved in DNA replication
DNA replication initiation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
positive regulation of cell proliferation
negative regulation of translation
cell differentiation
negative regulation of transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
mitotic cell cycle checkpoint
cell proliferation
