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PURA Antibody (PA5-98103) in WB
Western Blot analysis of PURA using a PURA Polyclonal antibody (Product # PA5-98103) at a concentration of 4.7 µg/mL. Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate. A secondary Goat polyclonal antibody to rabbit IgG was applied at a 1:50,000 dilution. Observed band size: 35 kDa.
产品信息
PA5-98103
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Transcriptional activator protein Pur-alpha protein (50-296AA)
偶联物
形式
Liquid
浓度
4.71 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_2812717
靶标信息
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: purine-rich element binding protein A; Purine-rich single-stranded DNA-binding protein alpha; Transcriptional activator protein Pur-alpha
基因别名: MRD31; PUR-ALPHA; PUR1; PURA; PURALPHA
UniProt ID: (Human) Q00577
Entrez Gene ID: (Human) 5813
translation repressor activity, nucleic acid binding
double-stranded telomeric DNA binding
single-stranded DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
transcription factor binding
purine-rich negative regulatory element binding
poly(A) RNA binding
SMAD binding
DNA-binding transcription factor
DNA unwinding involved in DNA replication
DNA replication initiation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
positive regulation of cell proliferation
negative regulation of translation
cell differentiation
negative regulation of transcription, DNA-templated
