Invitrogen

Pan Ankyrin Monoclonal Antibody (S388A-60)

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-27722

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:1,000
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

S388A-60

Immunogen

Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2735300

Target Information

Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton. Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers and ion transporters in the plasma membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ANK-1; ANK-2; ANK-3; ank2; ankyrin 1, erythrocytic; ankyrin 1, erythroid; ankyrin 2, brain; ankyrin 3 (G); ankyrin 3, epithelial; ankyrin B; ankyrin, brain; Ankyrin-1; Ankyrin-2; ankyrin-2, nonerythrocytic; Ankyrin-3; Ankyrin-B; Ankyrin-G; Ankyrin-R; Brain ankyrin; brain-specific ankyrin-G; Erythrocyte ankyrin; Non-erythroid ankyrin; normoblastic anemia; rCG_43073

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Gene Aliases: 2900054D09Rik; AI314020; AI835472; ANK; Ank-1; ANK-2; ANK-3; ANK1; ANK2; ANK3; ANKB; AnkG; Ankyrin-3; ANKYRIN-G; AW491075; brank-2; LQT4; MRT37; nb; pale; SPH1; SPH2

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UniProt ID: (Human) P16157, (Human) Q01484, (Human) Q12955, (Mouse) Q02357, (Mouse) Q8C8R3, (Rat) O70511, (Mouse) G5E8K5

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Entrez Gene ID: (Human) 286, (Human) 287, (Human) 288, (Mouse) 11733, (Rat) 306570, (Mouse) 109676, (Rat) 362036, (Rat) 361833, (Mouse) 11735

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Function(s)
structural molecule activity structural constituent of cytoskeleton protein binding cytoskeletal adaptor activity enzyme binding spectrin binding ATPase binding protein kinase binding protein binding, bridging ion channel binding cytoskeletal protein binding cadherin binding potassium channel regulator activity scaffold/adaptor protein membrane traffic protein
Process(es)
exocytosis ER to Golgi vesicle-mediated transport cytoskeleton organization signal transduction positive regulation of organelle organization maintenance of epithelial cell apical/basal polarity protein targeting to plasma membrane regulation of heart rate atrial septum development cellular calcium ion homeostasis positive regulation of gene expression regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of cardiac muscle contraction by calcium ion signaling paranodal junction assembly regulation of protein stability T-tubule organization protein localization to organelle protein localization to cell surface cellular protein localization protein localization to M-band protein localization to T-tubule positive regulation of potassium ion transport protein stabilization regulation of release of sequestered calcium ion into cytosol response to methylmercury regulation of calcium ion transport positive regulation of calcium ion transport regulation of cardiac muscle contraction regulation of ventricular cardiac muscle cell membrane repolarization sarcoplasmic reticulum calcium ion transport protein localization to endoplasmic reticulum protein localization to plasma membrane regulation of cardiac muscle cell contraction ventricular cardiac muscle cell action potential atrial cardiac muscle cell action potential SA node cell action potential membrane depolarization during SA node cell action potential atrial cardiac muscle cell to AV node cell communication SA node cell to atrial cardiac muscle cell communication regulation of heart rate by cardiac conduction regulation of SA node cell action potential regulation of atrial cardiac muscle cell action potential positive regulation of potassium ion transmembrane transporter activity regulation of calcium ion transmembrane transporter activity positive regulation of calcium ion transmembrane transporter activity positive regulation of cation channel activity mitotic cytokinesis plasma membrane organization cytoskeletal anchoring at plasma membrane axonogenesis axon guidance neuromuscular junction development positive regulation of cell communication by electrical coupling positive regulation of sodium ion transport magnesium ion homeostasis neuronal action potential positive regulation of homotypic cell-cell adhesion Golgi to plasma membrane protein transport regulation of potassium ion transport establishment of protein localization positive regulation of membrane potential cellular response to magnesium ion membrane assembly maintenance of protein location in plasma membrane positive regulation of protein targeting to membrane positive regulation of membrane depolarization during cardiac muscle cell action potential negative regulation of delayed rectifier potassium channel activity positive regulation of sodium ion transmembrane transporter activity porphyrin-containing compound biosynthetic process monovalent inorganic cation transport erythrocyte development iron ion homeostasis protein localization regulation of apoptotic process cardiac muscle contraction regulation of cardiac muscle cell membrane potential regulation of AV node cell action potential regulation of cation channel activity nervous system development synapse organization positive regulation of action potential
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