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Invitrogen
Peptidylarginine Deiminase Recombinant Rabbit Monoclonal Antibody (8M9P3)
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Peptidylarginine Deiminase Antibody (MA5-55302) in WB
Western blot analysis of lysates from wild type (WT) and 293T cells transfected with PADI1/PAD1 using Peptidylarginine Deiminase Recombinant Monoclonal Antibody (Product # MA5-55302) at 1:1,000 dilution incubated overnight at 4&(8)451; followed by a HRP-conjugated Goat anti-Rabbit IgG (H+L) secondary antibody at 1:10,000 dilution. Lysates/proteins: 20 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST... View More
产品信息
MA5-55302
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
8M9P3
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-277 of human PADI1/PAD1.
偶联物
形式
Liquid
浓度
1.43 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
产品详细信息
Immunogen Sequence: MAPKRVVQLS LKMPTHAVCV VGVEAHVDIH SDVPKGANSF RVSGSSGVEV FMVYNRTRVK EPIGKARWPL DTDADMVVSV GTASKELKDF KVRVSYFGEQ EDQALGRSVL YLTGVDISLE VDTGRTGKVK RSQGDKKTWR WGPEGYGAIL LVNCDRDNHR SAEPDLTHSW LMSLADLQDM SPMLLSCNGP DKLFDSHKLV LNVPFSDSKR VRVFCARGGN SLSDYKQVLG PQCLSYEVER QPGEQEIKFY VEGLTFPDAD FLGLVSLSVS LVDPGTL
靶标信息
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hPAD-colony 10; Pad type 1; PAD type I; PADI5; PDI2; PDI3; PDI4; peptidyl arginine deiminase, type I; Peptidylarginine deiminase I; Protein-arginine deiminase type I; PROTEIN-ARGININE DEIMINASE TYPE I (PEPTIDYLARGININE DEIMINASE I); Protein-arginine deiminase type-1
基因别名: AV236283; HPAD10; PAD1; PADI1; PDI; PDI1
UniProt ID: (Human) Q9ULC6, (Mouse) Q9Z185
Entrez Gene ID: (Human) 29943, (Mouse) 18599
