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Product Details
PA5-60020
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PPL. Recombinant protein control fragment (Product #RP-98660).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2645828
Product Specific Information
Immunogen sequence: LLAGLDKVAS DLDRQEKAIT GILRPPLEQG RAVQDSAERA KDLKNITNEL LRIEPEKTRS TAEGEAFIQA LPGSGTTPLL RTRVEDTNRK YEHLL
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 84%.
Target Information
The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 190 kDa paraneoplastic pemphigus antigen; 195 kDa cornified envelope precursor protein; MGC134872; Periplakin
Gene Aliases: KIAA0568; PPL
UniProt ID: (Human) O60437
Entrez Gene ID: (Human) 5493
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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