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Phospho-4EBP1/2/3 (Thr46, Thr32) Antibody (MA5-53650) in ICC/IF
Immunocytochemistry analysis of 4EBP1/2/3 in C2C12 cells. Nuclei were stained blue with DAPI; 4EBP1/2/3 recombinant monoclonal antibody (Product # MA5-53650) with a dilution of 1:1,000 was stained magenta with Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar: 20 μm.
产品信息
MA5-53650
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
23GB3850
抗原
A synthetic peptide of human Phospho-eIF4EBP1/2/3 (Thr46+Thr46+Thr32) (39-53AA).
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
靶标信息
4EBP1, 4EBP2, and 4EBP3 are members of the eukaryotic translation initiation factor 4E-binding protein (4EBP) family. These proteins play a crucial role in the regulation of protein synthesis, specifically by controlling the availability of the eukaryotic translation initiation factor 4E (eIF4E).| 4EBP1, 4EBP2, and 4EBP3 are structurally similar but exhibit some differences in their tissue distribution and expression levels. They are widely expressed in various tissues and cell types and have been implicated in the regulation of different biological processes, including cell growth, proliferation, and survival. Dysregulation of 4EBP proteins has also been associated with various diseases, including cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 4E-BP1; 4E-BP1/2/3; 4EBP1/2/3; BP-1/2/3; eIF4E-binding protein 1; EIF4E-Binding Protein 1/2/3; EIF4EBP1/2/3; Eukaryotic Translation Initiation Factor 4E Binding Protein 1/2/3; Eukaryotic translation initiation factor 4E-binding protein 1; Eukaryotic Translation Initiation Factor 4E-Binding Protein 1/2/3; PHAS-I; Phosphorylated heat- and acid-stable protein regulated by insulin 1; Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1/2/3
基因别名: 4E-BP1; 4EBP1; AA959816; BP-1; EIF4EBP1; PHAS-I
UniProt ID: (Human) Q13541, (Mouse) Q60876, (Rat) Q62622
Entrez Gene ID: (Human) 1978, (Mouse) 13685, (Rat) 116636
G1/S transition of mitotic cell cycle
IRES-dependent translational initiation
response to ischemia
insulin receptor signaling pathway
lung development
negative regulation of protein complex assembly
TOR signaling
response to ethanol
positive regulation of mitotic cell cycle
negative regulation of translational initiation
cellular response to hypoxia
regulation of translation
regulation of translational initiation
negative regulation of translation
