Invitrogen

Phospho-AKT1 (Thr342) Polyclonal Antibody

Phospho-AKT1 (Thr342) Antibody in Western Blot (WB)

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Phospho-AKT1 (Thr342) Antibody (PA5-95669) in WB

Western blot of AKT1 in Drosophila lysate showing specific labeling of the ~68 kDa corresponding to Phospho-AKT1 (Thr342) polyclonal antibody (Product # PA5-95669) in the first lane (-). Phosphospecificity is shown in the second lane (+) where the immunolabeling is completely eliminated by blot treatment with lambda phosphatase (1,200 units for 30 minutes).

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产品信息

PA5-95669

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500

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产品规格

种属反应

Fruit fly

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr342 conjugated to KLH

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.25 mg/mL

纯化类型

Antigen Affinity Chromatography

保存液

10mM HEPES, pH 7.5, with 100µg/mL BSA, 50% glycerol, 0.15M NaCl

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2807471

产品详细信息

Antigen Affinity Purified from Pooled Serum

靶标信息

AKT1 (PKB alpha) is a serine/threonine kinase that regulates cell survival. The activated enzyme inhibits apoptosis and stimulates cell cycle progression by phosphorylating numerous targets in various cell types, including cancer cells. This protein kinase is activated by insulin, PI3K, IGF1 and various other growth and survival factors. Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including forkhead transcription factors, and caspase-9. The AKT pathway is a major target for cancer drug discovery.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Study on Toll-Like Receptor 2-Mediated Inflammation-Induced Familial Hypertension Combined with Hyperlipemia and Its Mechanism.

Journal of healthcare engineering

Liu J,Li C,Wang Q,Hu H,Li C,Qian J

PA5-95669 was used in Western Blot to investigate the influence of Toll-like receptor 2- (TLR2-) mediated inflammation on the occurrence and development of familial hypertension combined with hyperlipemia and its related mechanism.

Thu Apr 21 00:00:00 UTC 2022

Sinoporphyrin sodium is a promising sensitizer for photodynamic and sonodynamic therapy in glioma.

Oncology reports

An YW,Liu HQ,Zhou ZQ,Wang JC,Jiang GY,Li ZW,Wang F,Jin HT

PA5-95669 was used in Western Blotting to explore the antitumor effects of sinoporphyrin sodium (DVDMS)‚mediated photodynamic therapy (PDT) and sonodynamic therapy (SDT) in glioma, and to reveal the underlying mechanisms.

Thu Oct 01 00:00:00 UTC 2020

Pulsed focused ultrasound enhances the therapeutic effect of mesenchymal stromal cell-derived extracellular vesicles in acute kidney injury.

Stem cell research & therapy

Ullah M,Liu DD,Rai S,Razavi M,Concepcion W,Thakor AS

PA5-95669 was used in Western Blotting to show that pFUS may be a strategy for enhancing the therapeutic efficacy of MSC-derived EV treatment for the treatment of AKI.

Mon Sep 14 00:00:00 UTC 2020

Pulsed focused ultrasound enhances the therapeutic effect of mesenchymal stromal cell-derived extracellular vesicles in acute kidney injury.

Stem cell research & therapy

Ullah M,Liu DD,Rai S,Razavi M,Concepcion W,Thakor AS

PA5-95669 was used in Western Blotting to show that pFUS may be a strategy for enhancing the therapeutic efficacy of MSC-derived EV treatment for the treatment of AKI.

Mon Sep 14 00:00:00 UTC 2020

生物信息学

蛋白别名: Akt kinase; Akt1-PA; Akt1-PB; Akt1-PC; Akt1-PD; Akt1-PE; C-AKT; CAKT; CG4006-PA; CG4006-PB; CG4006-PC; CG4006-PD; CG4006-PE; DAkt; dAkt kinase; PKB; PKB beta; PKB gamma; PKBG; Protein kinase B; RAC serine/threonine protein kinase; RAC serine/threonine-protein kinase; RAC-PK-beta; RAC-PK-gamma; related to PKA to PKC protein kinases; related to the A and C kinases; SD10374p

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基因别名: AKT; AKT/PKB; AKT1; Akt1|PKB; CG4006; D-Akt; DAKT; dAKT/dPKB; dAkt/PKB; DAKT1; DAKT1/PKB; Dmel\CG4006; Dmel_CG4006; DPKB; DRAC-PK; DRAC-PK66; DRAC-PK85; l(3)04226; l(3)89Bq; P-AKT; pAkt; PKB; PKB/AKT; PKB/dAKT; RAC; RacPK

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UniProt ID: (Fruit fly) Q8INB9

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Entrez Gene ID: (Fruit fly) 41957

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功能

protein serine/threonine kinase activity protein binding ATP binding non-receptor serine/threonine protein kinase

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