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Phospho-AKT2 (Ser474) Antibody (PA5-119813) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded mouse testis tissue using Phospho-AKT2 (Ser474) Polyclonal Antibody (Product # PA5-119813). The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the Phospho-AKT2 (S... View More
产品信息
PA5-119813
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide within human AKT2 aa 450-481(phospho S474)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2913385
产品详细信息
Positive Control: Hela treated with Calyculin A whole cell lysate, Hela treated with insulin whole cell lysate, human kidney tissue, mouse testis tissue.
Subcellular Location: Cell membrane, Nucleus, Early endosome, Cytoplasm.
靶标信息
AKT2 is a phosphoinositide-dependent serine/threonine protein kinase that is enriched in insulin responsive tissues and has been implicated in the metabolic actions of the hormone. Akt is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI 3-kinase). Akt2 is amplified and overexpressed in some human cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: murine thymoma viral (v-akt) homolog-2; PKB beta; Protein kinase Akt-2; Protein kinase B beta; protein kinase B, beta; putative v-akt murine thymoma viral oncoprotein 2; RAC protein kinase beta; RAC-beta serine/threonine protein kinase; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; v-akt murine thymoma viral oncogene homolog 2
基因别名: 2410016A19Rik; AKT2; AW554154; HIHGHH; PKB; PKBB; PKBBETA; PRKBB; RAC-BETA
UniProt ID: (Human) Q0VAN1, (Mouse) Q60823
Entrez Gene ID: (Human) 208, (Mouse) 11652
protein serine/threonine kinase activity
protein kinase C binding
protein binding
ATP binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein modifying enzyme
positive regulation of protein phosphorylation
glycogen biosynthetic process
glucose metabolic process
regulation of translation
cellular protein modification process
apoptotic process
response to osmotic stress
signal transduction
insulin receptor signaling pathway
carbohydrate transport
positive regulation of signal transduction
negative regulation of plasma membrane long-chain fatty acid transport
positive regulation of glucose metabolic process
response to muscle activity
peptidyl-serine phosphorylation
regulation of cell migration
positive regulation of cell migration
positive regulation of vesicle fusion
response to nutrient levels
positive regulation of fatty acid beta-oxidation
peripheral nervous system myelin maintenance
cellular response to insulin stimulus
negative regulation of RNA splicing
positive regulation of peptidyl-serine phosphorylation
intracellular signal transduction
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein kinase B signaling
positive regulation of nitric oxide biosynthetic process
fat cell differentiation
positive regulation of glycogen biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of glucose import
positive regulation of positive chemotaxis
mammary gland epithelial cell differentiation
intracellular protein transmembrane transport
regulation of cell cycle arrest
cellular response to organic cyclic compound
protein localization to plasma membrane
positive regulation of protein targeting to membrane
activation of GTPase activity
positive regulation of cell motility
positive regulation of glucose import in response to insulin stimulus
carbohydrate metabolic process
glycogen metabolic process
protein phosphorylation
transport
multicellular organism development
positive regulation of gene expression
positive regulation of sodium ion transport
phosphorylation
negative regulation of apoptotic process
