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Invitrogen
Phospho-Acetyl-CoA Carboxylase (Thr1196) Polyclonal Antibody
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Phospho-Acetyl-CoA Carboxylase (Thr1196) Antibody (PA5-105629) in ICC/IF
Immunofluorescent analysis of Phospho-Acetyl-CoA Carboxylase (Thr1196) in HepG2 cells(4h of LPS treatment). Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Phospho-Acetyl-CoA Carboxylase (Thr1196) polyclonal antibody (Product # PA5-105629) using a dilution of 1:200 (1 hr, 37°C), and followed b... View More
产品信息
PA5-105629
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ACACA(Accession Q13085), corresponding to amino acid residues around phosphorylated Thr1196.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2817057
产品详细信息
Antibody detects endogenous levels of ACC1 only when phosphorylated at Thr1196.
靶标信息
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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