Invitrogen

Phospho-C-Jun/D-Jun (Ser73, Ser100) Recombinant Rabbit Monoclonal Antibody (23GB4495)

说明书
实验方案
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说明书
实验方案
技术支持

产品信息

MA5-52704

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:5,000
-

免疫细胞化学 (ICC/IF)

1:1,000
-

流式细胞分析 (Flow)

1:2,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293F

分类

Recombinant Monoclonal

类型

Antibody

克隆号

23GB4495

抗原

A synthesized peptide derived from human Phospho-c-Jun (Ser73)+JunD (Ser100) (66-80AA).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

靶标信息

C-Jun/D-Jun are members of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Activator Protein 1; AH119; AP-1; AP1; Avian sarcoma virus 17 (v-jun) oncogene homolog; C-JUN; CJUN; Enhancer-Binding Protein AP1; immediate early; Jun A; Jun Activation Domain Binding Protein; jun D proto-oncogene; Jun Oncogene; jun proto-oncogene; Jun proto-oncogene related gene d; Jun proto-oncogene related gene d1; Jun Proto-Oncogene, AP-1 Transcription Factor Subunit; JunD-FL isoform; P39; Proto-oncogene c-Jun; Proto-Oncogene CJun; Transcription Factor AP-1; Transcription Factor AP-1 Subunit Jun; Transcription factor AP-1 subunit JunD; Transcription Factor Jun; transcription factor jun-D; Transcription factor JunD; V-Jun Avian Sarcoma Virus 17 Oncogene Homolog; v-jun sarcoma virus 17 oncogene homolog

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基因别名: AP-1; AP1; c-Jun; JUN; Jun-d; Junc; JUND; Jund1; Rjg-9

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UniProt ID: (Human) P05412, (Human) P17535, (Rat) P17325, (Mouse) P05627, (Rat) P52909, (Mouse) P15066

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Entrez Gene ID: (Human) 3725, (Human) 3727, (Rat) 24516, (Mouse) 16476, (Rat) 24518, (Mouse) 16478

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功能
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II transcription factor binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription coactivator activity GTPase activator activity protein binding transcription factor binding enzyme binding cAMP response element binding identical protein binding protein homodimerization activity transcription regulatory region DNA binding poly(A) RNA binding protein heterodimerization activity R-SMAD binding HMG box domain binding ligand-dependent nuclear receptor binding double-stranded DNA binding sequence-specific DNA binding basic leucine zipper transcription factor
参与通路
angiogenesis microglial cell activation release of cytochrome c from mitochondria liver development positive regulation of endothelial cell proliferation outflow tract morphogenesis transcription from RNA polymerase II promoter transforming growth factor beta receptor signaling pathway SMAD protein import into nucleus Ras protein signal transduction aging learning circadian rhythm negative regulation of cell proliferation response to radiation response to mechanical stimulus positive regulation of epithelial cell migration regulation of cell death monocyte differentiation axon regeneration negative regulation of protein autophosphorylation response to lipopolysaccharide cellular response to hormone stimulus response to cytokine leading edge cell differentiation response to muscle stretch Fc-epsilon receptor signaling pathway regulation of cell proliferation response to drug response to hydrogen peroxide negative regulation of DNA binding negative regulation of neuron apoptotic process positive regulation of neuron apoptotic process positive regulation of GTPase activity negative regulation by host of viral transcription positive regulation by host of viral transcription positive regulation of cell differentiation positive regulation of monocyte differentiation positive regulation of DNA replication negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of fibroblast proliferation positive regulation of smooth muscle cell proliferation regulation of sequence-specific DNA binding transcription factor activity cellular response to potassium ion starvation response to cAMP regulation of cell cycle membrane depolarization SMAD protein signal transduction eyelid development in camera-type eye positive regulation of ERK1 and ERK2 cascade cellular response to calcium ion positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress positive regulation of DNA-templated transcription, initiation negative regulation of transcription from RNA polymerase II promoter osteoblast development regulation of transcription from RNA polymerase II promoter response to light stimulus response to peptide hormone positive regulation of osteoblast differentiation transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of cell proliferation cellular process response to organic substance response to organic cyclic compound positive regulation of apoptotic process negative regulation of apoptotic process
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