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Phospho-CDK1 (Tyr15) Antibody (PA5-85508) in IHC (P)
Phospho-CDK1 (Tyr15) Polyclonal Antibody detects CDC2 (phospho Tyr15) protein at cytoplasm in human endometrial carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human endometrial carcinoma. Phospho-CDK1 (Tyr15) Polyclonal Antibody (Product # PA5-85508) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
产品信息
PA5-85508
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carrier-protein conjugated synthetic peptide corresponding to residues around human CDC2 (phospho Tyr15).
偶联物
形式
Liquid
浓度
0.84 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2792648
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (100%), Japanese Medaka (100%), Drosophila (100%), Xenopus laevis (100%), Pig (100%), Chicken (100%), Sheep (100%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (100%).
Positive Control: HeLa (untreated), HeLa (2mM double thymidine treatment and recovery for 3.5hr), HeLa (2mM double thymidine treatment and recovery for 12hr), HeLa (100 ng/mL Nocodazole treatment for 24hr), Rat-2 (untreated), Rat-2 (100 ng/mL Nocodazole treatment for 24.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
CDK1 or Cell Division Control protein 1 is essential for the completion of START, the controlling event in the cell cycle that is required to initiate mitosis. CDK1 is a catalytic subunit of a protein kinase complex, called the M-Phase Promoting Factor that induces entry into mitosis and is universal among eukaryotes. Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ABL1; CDK1; cell cycle controller CDC2; Cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; Cell division protein kinase 1; Cyclin-dependent kinase 1; DKFZp686L20222; KCIP-1; MGC111195; MGC53829; OTTHUMP00000019660; P34 CDK1; P34 MGC111195; p34 protein kinase; Protein 1054
基因别名: CDC2; CDC28A; CDK1; CDKN1; P34CDC2
UniProt ID: (Human) P06493
Entrez Gene ID: (Human) 983
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
RNA polymerase II carboxy-terminal domain kinase activity
cyclin binding
Hsp70 protein binding
histone kinase activity
non-receptor serine/threonine protein kinase
G1/S transition of mitotic cell cycle
regulation of transcription involved in G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
activation of MAPK activity
microtubule cytoskeleton organization
DNA replication
DNA repair
protein complex assembly
apoptotic process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
mitotic nuclear division
mitotic nuclear envelope disassembly
mitotic G2 DNA damage checkpoint
centrosome cycle
pronuclear fusion
cell aging
response to toxic substance
positive regulation of gene expression
regulation of Schwann cell differentiation
response to organic cyclic compound
response to amine
response to activity
cell migration
histone phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
chromosome condensation
epithelial cell differentiation
organ regeneration
anaphase-promoting complex-dependent catabolic process
positive regulation of protein import into nucleus, translocation
protein localization to kinetochore
response to drug
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
response to ethanol
positive regulation of DNA replication
positive regulation of mitotic cell cycle
regulation of embryonic development
response to cadmium ion
response to copper ion
response to axon injury
cell division
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
ventricular cardiac muscle cell development
positive regulation of cardiac muscle cell proliferation
cellular response to hydrogen peroxide
Golgi disassembly
positive regulation of protein localization to nucleus
