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产品信息
PA5-77906
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human CDK2 (phospho Thr160). The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
3.35 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2736359
产品详细信息
Positive Control: 293T, HeLa, HeLa (10 mM Hydroxyurea treatment for 18 hr)
Predicted Reactivity: Mouse (100%), Rat (100%), Zebrafish (100%), Pig (100%), Chicken (100%), Sheep (100%), Bovine (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
CDK2/cyclinO is a member of the cyclin dependent protein kinase family complexed to CyclinO. CyclinO was used as a specific protein isoform name for the UNG gene which is localized exclusively in the nucleus. In addition, CyclinO was reported to shows significant uracil-DNA glycosylase activity. CDK2/cyclinO protein levels increase during G1 phase and the protein is turned over during the course of cell cycle. The levels of cyclin A-cdk2 is maximal at the G1/S transition and both cdk2 and cyclin A are found associated with DNA in the initiation complex during replication. Rb protein acts as substrate for cdk2-cyclin E and/or cdk2-cyclin A in vivo. Cdk2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cdc2-related protein kinase; CDC28; CDC2A; CDK1; Cell division protein kinase 2; Cyclin-dependent kinase 2; EC 2.7.11.22; EC 2.7.11.23; kinase Cdc2; MPF; p33 protein kinase; p33CDK2; p34 protein kinase
基因别名: CDK2; CDKN2; p33(CDK2)
UniProt ID: (Human) P24941
Entrez Gene ID: (Human) 1017
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
lens development in camera-type eye
DNA replication
DNA repair
potassium ion transport
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
mitotic nuclear division
centriole replication
meiotic nuclear division
Ras protein signal transduction
positive regulation of cell proliferation
response to toxic substance
histone phosphorylation
peptidyl-serine phosphorylation
organ regeneration
mitotic G1 DNA damage checkpoint
positive regulation of DNA-dependent DNA replication initiation
response to estradiol
cellular response to insulin stimulus
response to drug
response to ethanol
positive regulation of transcription, DNA-templated
response to cadmium ion
centrosome duplication
cell division
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
response to cAMP
response to electrical stimulus
regulation of gene silencing
cellular response to nitric oxide
regulation of signal transduction by p53 class mediator
