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Phospho-CDK2 (Tyr15) Antibody (MA5-50316) in WB
Western Blot analysis of Phospho-CDK2 (Tyr15) using Phospho-CDK2 (Tyr15) Recombinant Monoclonal Antibody (Product # MA5-50316) in Untreated (–) and treated (+) NIH-3T3 whole cell extracts (30 μg) at a dilution of 1:1,000. Extracts were separated by 12% SDS-PAGE. An HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
产品信息
MA5-50316
产品规格
种属反应
Fruit fly,
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1474
抗原
Carrier-protein conjugated synthetic peptide corresponding to residues around human CDK2 (phospho Tyr15). The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3094391
靶标信息
CDK2/cyclinO is a member of the cyclin dependent protein kinase family complexed to CyclinO. CyclinO was used as a specific protein isoform name for the UNG gene which is localized exclusively in the nucleus. In addition, CyclinO was reported to shows significant uracil-DNA glycosylase activity. CDK2/cyclinO protein levels increase during G1 phase and the protein is turned over during the course of cell cycle. The levels of cyclin A-cdk2 is maximal at the G1/S transition and both cdk2 and cyclin A are found associated with DNA in the initiation complex during replication. Rb protein acts as substrate for cdk2-cyclin E and/or cdk2-cyclin A in vivo. Cdk2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cdc2-related protein kinase; CDC28; CDC2A; cdc2c; CDK1; Cdk2-PA; Cdk2-PB; Cdk2-PC; Cell division control protein 2 cognate; Cell division protein kinase 2; CG10498-PA; CG10498-PB; CG10498-PC; cyclin dependent kinase 2-alpha; cyclin E; Cyclin-dependent kinase 2; EC 2.7.11.22; EC 2.7.11.23; kinase Cdc2; LD22351p; MPF; p33 protein kinase; p33CDK2; p34 protein kinase
基因别名: A630093N05Rik; CDC2C; CDK2; CDK2/CDC2c; CDKN2; CG10498; Dcdc2c; dCdk2; DmCdc2c; DmCdk2; Dmel\CG10498; Dmel_CG10498; p33(CDK2); S(Sev-CycE)3A
UniProt ID: (Human) P24941, (Mouse) P97377, (Fruit fly) P23573
Entrez Gene ID: (Human) 1017, (Rat) 362817, (Mouse) 12566, (Fruit fly) 42453
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
cyclin binding
protein complex binding
histone kinase activity
metal ion binding
protein kinase activity
nucleotide binding
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
lens development in camera-type eye
DNA replication
DNA repair
potassium ion transport
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
mitotic nuclear division
centriole replication
meiotic nuclear division
Ras protein signal transduction
positive regulation of cell proliferation
response to toxic substance
histone phosphorylation
peptidyl-serine phosphorylation
organ regeneration
mitotic G1 DNA damage checkpoint
positive regulation of DNA-dependent DNA replication initiation
response to estradiol
cellular response to insulin stimulus
response to drug
response to ethanol
positive regulation of transcription, DNA-templated
response to cadmium ion
centrosome duplication
cell division
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
response to cAMP
response to electrical stimulus
regulation of gene silencing
cellular response to nitric oxide
regulation of signal transduction by p53 class mediator
protein phosphorylation
meiotic cell cycle
regulation of cell cycle
cellular response to DNA damage stimulus
cell cycle
phosphorylation
signal transduction
regulation of G2/M transition of mitotic cell cycle
regulation of gene expression
positive regulation of JAK-STAT cascade
