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Phospho-Catenin alpha-1 (Tyr177) Antibody (PA5-105563) in WB
Western blot analysis of Phospho-Catenin alpha-1 (Tyr177) in HeLa cell lysate (Lane 1: treated with phospho-blocking peptide; Lane 2: treated with non-phospho-blocking peptide). Samples were incubated with Phospho-Catenin alpha-1 (Tyr177) polyclonal antibody (Product # PA5-105563).
产品信息
PA5-105563
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CTNNA1(Accession P35221), corresponding to amino acid residues around phosphorylated Tyr177.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2816991
产品详细信息
Antibody detects endogenous levels of alpha 1 Catenin only when phosphorylated at Tyr177.
靶标信息
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherence junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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