Invitrogen

Phospho-Chk2 (Thr383) Polyclonal Antibody

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产品信息

PA5-104714

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:100
-

免疫细胞化学 (ICC/IF)

1:100-1:500
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human CHEK2(Accession O96017), corresponding to amino acid residues around phosphorylated Thr383.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

sequential chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2816187

产品详细信息

Antibody detects endogenous levels of Chk2 only when phosphorylated at Threonine 383.

靶标信息

CHEK2 (CHK2) is a serine/threonine kinase and a component of the DNA damage checkpoint pathway. A mutation in CHK2 has been linked to cancer. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control including tumor suppressor proteins. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familiar cancer usually associated with inherited mutations in TP53. Also, mutations in CHK2 are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Cds1 homolog; Checkpoint kinase 2; Checkpoint like protein CHK2; checkpoint-like protein CHK2; Chk2 (phospho T68); Chk2 (pThr68); CHK2 checkpoint homolog; CHK2 checkpoint homolog (S. pombe); Chk2 phospho; Chk2 phospho T68; del9; EC 2.7.11.1; HuCds 1; Hucds1; kinase Chk2; OTTHUMP00000199044; OTTHUMP00000199045; OTTHUMP00000199064; OTTHUMP00000199115; OTTHUMP00000199116; phospho Chk2 (T68); phospho Thr68 Chk2; protein kinase Chk2; Rad53 homolog; RP11-436C9.1; Serine/threonine protein kinase Chk2; Serine/threonine-protein kinase Chk2

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基因别名: CDS1; CHEK2; CHK2; hCds1; HUCDS1; LFS2; PP1425; RAD53

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UniProt ID: (Human) O96017, (Mouse) Q9Z265

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Entrez Gene ID: (Human) 11200, (Mouse) 50883, (Rat) 114212

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功能
protein serine/threonine kinase activity protein binding ATP binding protein kinase binding ubiquitin protein ligase binding identical protein binding protein homodimerization activity metal ion binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
参与通路
DNA damage checkpoint G2/M transition of mitotic cell cycle replicative cell aging positive regulation of protein phosphorylation double-strand break repair transcription, DNA-templated regulation of transcription, DNA-templated protein phosphorylation cellular response to DNA damage stimulus DNA damage induced protein phosphorylation DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest intrinsic apoptotic signaling pathway in response to DNA damage response to gamma radiation peptidyl-serine phosphorylation cellular response to drug regulation of protein catabolic process signal transduction in response to DNA damage cellular protein catabolic process positive regulation of transcription, DNA-templated protein autophosphorylation protein stabilization cell division negative regulation of cell cycle arrest signal transduction involved in intra-S DNA damage checkpoint mitotic spindle assembly replicative senescence regulation of signal transduction by p53 class mediator response to doxorubicin cellular response to bisphenol A negative regulation of DNA damage checkpoint positive regulation of anoikis DNA repair apoptotic process cell cycle mitotic nuclear division phosphorylation
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