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产品信息
PA5-64665
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CtBP1/2 (Phospho-Ser158/164)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2663240
产品详细信息
Phospho-CtBP1/CtBP2 (Ser158, 164) Polyclonal Antibody detects endogenous levels of CtBP1/CtBP2 only when phosphorylated at Ser158, 164.
靶标信息
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: brefeldin A-ribosylated substrate; C-terminal-binding protein 1; C-terminal-binding protein 2; CtBP1; CtBP2; ribeye
基因别名: BARS; CTBP; CTBP1; CTBP2
UniProt ID: (Human) Q13363, (Human) P56545
Entrez Gene ID: (Human) 1487, (Human) 1488
RNA polymerase II transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
protein binding
protein C-terminus binding
transcription factor binding
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
protein domain specific binding
protein homodimerization activity
NAD binding
repressing transcription factor binding
chromatin binding
transcription coactivator activity
transcription corepressor activity
retinoic acid receptor binding
transcription cofactor
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
protein phosphorylation
negative regulation of cell proliferation
viral genome replication
positive regulation of histone deacetylation
negative regulation of histone acetylation
negative regulation of transcription, DNA-templated
white fat cell differentiation
regulation of cell cycle
oxidation-reduction process
negative regulation of histone H4 acetylation
negative regulation of transcription from RNA polymerase II promoter by histone modification
positive regulation of chromatin binding
positive regulation of transcription from RNA polymerase II promoter
positive regulation of retinoic acid receptor signaling pathway
