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Phospho-DNA-PK (Ser2612) Antibody (PA5-105789) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-DNA-PK (Ser2612) in mouse kidney tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-DNA-PK (Ser2612) polyclonal antibody (Product # PA5-105789) using a dilution of 1:200 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
产品信息
PA5-105789
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PRKDC(Accession P78527), corresponding to amino acid residues around phosphorylated Ser2612.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2817188
产品详细信息
Antibody detects endogenous levels of DNA-PK only when phosphorylated at Ser2612.
靶标信息
DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. DNA-PK is an atypical kinase, closely related to the PI3 kinases, and is often potently inhibited by small molecules designed to target PI3 kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for DNA-PK.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNPK1; doxorubicin nephropathy; hyper-radiosensitivity of murine scid mutation, complementing 1; p460; severe combined immunodeficiency
基因别名: AI326420; AU019811; DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH; dxnph; HYRC; HYRC1; IMD26; p350; p460; PRKDC; scid; slip; XRCC7
UniProt ID: (Human) P78527, (Mouse) P97313
Entrez Gene ID: (Human) 5591, (Mouse) 19090, (Rat) 360748
double-stranded DNA binding
protein kinase activity
protein serine/threonine kinase activity
DNA-dependent protein kinase activity
protein binding
ATP binding
transcription factor binding
enzyme binding
poly(A) RNA binding
nucleotide binding
DNA binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
phosphotransferase activity, alcohol group as acceptor
molecular_function
non-receptor serine/threonine protein kinase
protein modifying enzyme
somitogenesis
negative regulation of protein phosphorylation
B cell lineage commitment
pro-B cell differentiation
T cell lineage commitment
negative regulation of immunoglobulin production
positive regulation of immune system process
double-strand break repair
double-strand break repair via nonhomologous end joining
cellular protein modification process
brain development
heart development
cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage
response to gamma radiation
response to activity
telomere capping
peptidyl-serine phosphorylation
protein destabilization
positive regulation of type I interferon production
cellular response to insulin stimulus
T cell differentiation in thymus
immunoglobulin V(D)J recombination
T cell receptor V(D)J recombination
ectopic germ cell programmed cell death
regulation of circadian rhythm
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
rhythmic process
spleen development
thymus development
positive regulation of developmental growth
regulation of smooth muscle cell proliferation
signal transduction involved in mitotic G1 DNA damage checkpoint
double-strand break repair via alternative nonhomologous end joining
negative regulation of cellular senescence
negative regulation of response to gamma radiation
telomere maintenance
double-strand break repair via homologous recombination
immunoglobulin production
DNA repair
protein phosphorylation
cellular response to DNA damage stimulus
response to ionizing radiation
phosphorylation
lymphocyte differentiation
V(D)J recombination
