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Phospho-EPS15 (Tyr849) Antibody (PA5-118497) in IHC (P)
Immunohistochemical analysis of Phospho-EPS15 (Tyr849) in Mouse muscle tissue using a Phospho-EPS15 (Tyr849) polyclonal antibody (Product # PA5-118497). The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the primary antibody at 4°C overnight. An HRP conjugated anti-Rabbit antibody was used as the second... View More
产品信息
PA5-118497
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human EPS15(Accession P42566), corresponding to amino acid residues around phosphorylated Tyr849.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2902999
产品详细信息
Antibody detects endogenous levels of EPS15 only when phosphorylated at Tyrosine 849.
靶标信息
EPS15 is a ubiquitously expressed protein that is involved in cell growth regulation and may be involved in the regulation of mitogenic signals and control of cell proliferation. Phosphorylation of EPS15 on Tyrosine 849 upon DNA damage is involved in the internalization of EGFR. A chromosomal aberration involving EPS15 is also found in acute leukemias, resulting in a rogue activator protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AF-1p protein; ALL1 fused gene from chromosome 1; epidermal growth factor pathway substrate 15; Epidermal growth factor receptor substrate 15; Protein AF-1p; Protein Eps15
基因别名: 2410112D09Rik; AF-1P; AF1P; EPS15; MLLT5; RGD1307641
UniProt ID: (Human) P42566, (Mouse) P42567
Entrez Gene ID: (Human) 2060, (Mouse) 13858, (Rat) 313474
Golgi to endosome transport
epidermal growth factor receptor signaling pathway
cell proliferation
protein transport
vesicle organization
receptor-mediated endocytosis of virus by host cell
endocytic recycling
negative regulation of epidermal growth factor receptor signaling pathway
viral entry into host cell
clathrin coat assembly
cell-cell adhesion
positive regulation of receptor recycling
transport
endocytosis
regulation of cell proliferation
