Invitrogen

Phospho-EphA2/EphA5 (Tyr594) Polyclonal Antibody

产品信息

PA5-37812

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

-

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Peptide sequence around phosphorylation site of tyrosine 594 (H-T-Y(p)-E-D) derived from Human EPHA2/5.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

AB_2554420

产品详细信息

A suggested positive control for Western blot is JK cells.

靶标信息

These proteins belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Brain-specific kinase; CEK-7; eck-like sequence 1; EHK-1; EK7; EPH homology kinase 1; EPH-like kinase 7; Ephrin A2; Ephrin A5; Ephrin type-A receptor 2; Ephrin type-A receptor 5; EphrinA2; EphrinA5; Epithelial cell kinase; epithelial cell receptor protein tyrosine kinase; receptor protein-tyrosine kinase HEK7; soluble EPHA2 variant 1; Tyrosine-protein kinase receptor ECK; tyrosine-protein kinase receptor EHK-1; Tyrosine-protein kinase receptor MPK-5; Tyrosine-protein kinase receptor SEK-2

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基因别名: AI854630; ARCC2; AW125296; AW545284; BSK; CEK7; CTPA; CTPP1; CTRCT6; ECK; EHK-1; EHK1; EK7; Els1; EPHA2; EPHA5; HEK7; Myk2; Rek7; Sek-2; Sek2; TYRO4

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UniProt ID: (Human) P29317, (Human) P54756, (Mouse) Q03145, (Mouse) Q60629

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Entrez Gene ID: (Human) 1969, (Human) 2044, (Mouse) 13836, (Mouse) 13839

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transmembrane receptor protein tyrosine kinase activity ephrin receptor activity protein binding ATP binding cadherin binding involved in cell-cell adhesion GPI-linked ephrin receptor activity transmembrane-ephrin receptor activity nucleotide binding protein kinase activity protein tyrosine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups growth factor receptor binding transmembrane signal receptor

skeletal system development angiogenesis vasculogenesis osteoblast differentiation multicellular organism development intrinsic apoptotic signaling pathway in response to DNA damage regulation of lamellipodium assembly notochord formation viral process cell migration peptidyl-tyrosine phosphorylation neural tube development neuron differentiation keratinocyte differentiation osteoclast differentiation mammary gland epithelial cell proliferation regulation of cell adhesion mediated by integrin post-anal tail morphogenesis protein kinase B signaling regulation of blood vessel endothelial cell migration regulation of angiogenesis bone remodeling ephrin receptor signaling pathway axial mesoderm formation negative regulation of protein kinase B signaling notochord cell development cell chemotaxis branching involved in mammary gland duct morphogenesis lens fiber cell morphogenesis regulation of ERK1 and ERK2 cascade response to growth factor positive regulation of establishment of protein localization to plasma membrane activation of GTPase activity cell-cell adhesion axon guidance cAMP-mediated signaling hippocampus development positive regulation of CREB transcription factor activity regulation of actin cytoskeleton organization regulation of GTPase activity neuron development regulation of insulin secretion involved in cellular response to glucose stimulus blood vessel development protein phosphorylation apoptotic process cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway phosphorylation cell differentiation notochord morphogenesis nervous system development positive regulation of phosphatidylinositol 3-kinase signaling negative regulation of synapse assembly dendritic spine morphogenesis