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Phospho-FES (Tyr713) Antibody (PA5-105783) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-FES (Tyr713) in mouse kidney tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-FES (Tyr713) polyclonal antibody (Product # PA5-105783) using a dilution of 1:200 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
产品信息
PA5-105783
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human FES(Accession P07332), corresponding to amino acid residues around phosphorylated Tyr713.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2817182
产品详细信息
Antibody detects endogenous levels of FES only when phosphorylated at Tyr713.
靶标信息
FES (FPS) is a tyrosine protein kinase that is required for maintenance of cellular transformation. Its chromosomal location is linked to a specific translocation event identified in patients with acute promyelocytic leukemia, and it is also involved in normal hematopoiesis. Alternative splicing results in multiple variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: EC 2.7.10.2; feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog; feline sarcoma oncogene; Feline sarcoma/Fujinami avian sarcoma oncogene homolog; Oncogene FES, feline sarcoma virus; p93c-fes; Proto-oncogene c-Fes; Proto-oncogene c-Fps; proto-oncogene tyrosine-protein kinase Fes/Fps; tyrosine kinase Fps/Fes; Tyrosine-protein kinase Fes/Fps; Variant 4
基因别名: AI586313; BB137047; c-fes; FES; FPS; RGD1564385
UniProt ID: (Human) P07332, (Mouse) P16879
Entrez Gene ID: (Human) 2242, (Mouse) 14159, (Rat) 361597
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
protein binding
ATP binding
microtubule binding
immunoglobulin receptor binding
phosphatidylinositol binding
nucleotide binding
protein kinase activity
receptor binding
lipid binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
microtubule bundle formation
protein phosphorylation
chemotaxis
cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of cell shape
positive regulation of neuron projection development
phosphorylation
cell migration
peptidyl-tyrosine phosphorylation
cell differentiation
regulation of cell adhesion
positive regulation of microtubule polymerization
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
regulation of mast cell degranulation
innate immune response
regulation of cell differentiation
positive regulation of myeloid cell differentiation
protein autophosphorylation
centrosome organization
regulation of cell motility
positive regulation of actin cytoskeleton reorganization
epidermal growth factor receptor signaling pathway
multicellular organism development
cell proliferation
regulation of vesicle-mediated transport
