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产品信息
PA5-37785
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide sequence around phosphorylation site of tyrosine 436(L-N-Y(p)-I-Q) derived from Human FRS2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2554393
产品详细信息
A suggested positive control for Western blot is HUVEC or JK cells; suggested positive control for IHC is human brain tissue.
靶标信息
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FGFR signalling adaptor; FGFR substrate 2; FGFR-signaling adaptor SNT; Fibroblast growth factor receptor substrate 2; SNT-1; SNT2; Suc1-associated neurotrophic factor target 1
基因别名: FRS1A; FRS2; FRS2A; FRS2alpha; SNT; SNT-1; SNT1
UniProt ID: (Human) Q8WU20
Entrez Gene ID: (Human) 10818
transmembrane receptor protein tyrosine kinase adaptor activity
Ras guanyl-nucleotide exchange factor activity
fibroblast growth factor receptor binding
insulin receptor binding
neurotrophin TRKA receptor binding
protein binding
1-phosphatidylinositol-3-kinase activity
phosphatase activator activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
MAPK cascade
activation of MAPKK activity
activation of MAPK activity
gastrulation with mouth forming second
organ induction
ventricular septum development
transmembrane receptor protein tyrosine phosphatase signaling pathway
G-protein coupled receptor signaling pathway
neuroblast proliferation
fibroblast growth factor receptor signaling pathway
anterior/posterior axis specification, embryo
regulation of phosphatidylinositol 3-kinase signaling
forebrain development
phosphatidylinositol-3-phosphate biosynthetic process
regulation of apoptotic process
positive regulation of GTPase activity
optic placode formation involved in camera-type eye formation
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
regulation of epithelial cell proliferation
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
lens fiber cell development
regulation of ERK1 and ERK2 cascade
