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产品信息
PA5-37778
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide sequence around phosphorylation site of tyrosine 643(V-D-Y(p)-V-Q) derived from Human Gab2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2554386
产品详细信息
A suggested positive control for Western blot is NIH-3T3 cells; suggested positive control for IHC is human brain tissue.
靶标信息
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Grb2 associated binder 2; GRB2-associated binder 2; GRB2-associated binding protein 2; GRB2-associated-binding protein 2; GRB3-3; Growth factor receptor bound protein 2-associated protein 2; PH domain-containing adaptor molecule p97; pp100
基因别名: AI463667; D130058I17Rik; GAB2; KIAA0571; p97
UniProt ID: (Human) Q9UQC2, (Rat) Q9EQH1
Entrez Gene ID: (Human) 9846, (Rat) 84477, (Mouse) 14389
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
osteoclast differentiation
Fc-epsilon receptor signaling pathway
positive regulation of mast cell degranulation
phosphatidylinositol-mediated signaling
integrin-mediated signaling pathway
cell migration
intracellular signal transduction
positive regulation of signal transduction
