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Phospho-GAP43 (Ser41) Antibody (PA1-4626) in WB
Western blot of GAP43 in rat cortical lysate showing specific immunolabeling of a band at ~50 kDa corresponding to Phospho-GAP43 (Ser41) polyclonal antibody (Product # PA1-4626) in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is completely eliminated by blot treatment with lambda phosphatase (1,200 units for 30 min).
产品信息
PA1-4626
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser41 of rat GAP43 conjugated to KLH
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2263255
产品详细信息
This antibody is predicted to react with bovine, canine, chicken, finch, human, mouse, non-human primate, Xenopus and zebrafish based on 100% sequence homology.
This antibody is specific for the ~50 kDa Gap-43 protein phosphorylated at Ser41 in Western blots of rat brain lysate. In some tissues the antibody also recognizes a higher molecular weight protein, that is also recognized by the Pan Gap-43 antibody, that may be a Gap-43 aggregate or oligomer. Immunolabeling blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide.
靶标信息
GAP43 (Neuromodulin) is associated with nerve growth. GAP43 is expressed by developing and regenerating neurons, and to a lesser extent reactive glial cells. It is a major component of the motile "growth cones" that form the tips of elongating axons. GAP43 also plays a role in axonal and dendritic filopodia induction.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Axonal membrane protein GAP-43; brain abundant, membrane attached signal protein 2; Calmodulin-binding protein P-57; growth accentuating protein 43; Growth-associated protein 43; MGC156666; Neuromodulin; neuron protein F1; Protein F1
基因别名: B-50; Basp2; GAP-43; Gap43
UniProt ID: (Rat) P07936, (Mouse) P06837
Entrez Gene ID: (Rat) 29423, (Mouse) 14432
