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Phospho-GluR2 (Tyr876) Antibody (PA5-17096) in WB
Western blot analysis of Phospho-AMPA Receptor pTyr876 in extracts from rat brain, either sham-operated, 15 min ischemia followed by 4 h reperfusion, or 15 min ischemia only, using Phospho-AMPA Receptor pTyr876 polyclonal antibody (Product # PA5-17096) (upper) or an AMPA Receptor (GluR 2/3/4) polyclonal antibody (lower).
产品信息
PA5-17096
应用
建议稀释比
已发表文章
产品规格
种属反应
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phosphopeptide corresponding to residues surrounding pTyr876 of human GluR 2
偶联物
形式
Liquid
浓度
125 µg/mL
纯化类型
Antigen affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_10982287
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5 -methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct Glutamate Receptor Subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain. The GluR2 subunit is thought to play a key role in forms of synaptic plasticity such as LTD.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: AMPA-selective glutamate receptor 2; GluA2; GluR-2; GluR-B; GluR-K2; glutamate receptor; Glutamate receptor 2; glutamate receptor B; Glutamate receptor ionotropic, AMPA 2; OTTHUMP00000165324; OTTHUMP00000220942; OTTHUMP00000220943
基因别名: GluA2; gluR-B; GluR-K2; GluR2; Gria2
UniProt ID: (Rat) P19491
Entrez Gene ID: (Rat) 29627
receptor activity
ionotropic glutamate receptor activity
AMPA glutamate receptor activity
extracellular-glutamate-gated ion channel activity
calcium channel regulator activity
protein binding
kainate selective glutamate receptor activity
protein kinase binding
PDZ domain binding
identical protein binding
regulation of receptor recycling
chemical synaptic transmission
response to lithium ion
receptor internalization
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
establishment of protein localization
positive regulation of synaptic transmission
protein tetramerization
regulation of synaptic transmission, glutamatergic
response to fungicide
