Invitrogen

Phospho-HDAC4/HDAC5/HDAC9 (Ser246, Ser259, Ser220) Recombinant Rabbit Monoclonal Antibody (8H4J9)

Phospho-HDAC4/HDAC5/HDAC9 (Ser246, Ser259, Ser220) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Phospho-HDAC4/HDAC5/HDAC9 (Ser246, Ser259, Ser220) Antibody (MA5-51562) in IHC (P)

Immunohistochemistry analysis of Phospho-HDAC4/HDAC5/HDAC9 (Ser246, Ser259, Ser220) in paraffin-embedded mouse kidney. Samples were incubated with Phospho-HDAC4/HDAC5/HDAC9 (Ser246, Ser259, Ser220) Recombinant monoclonal antibody (Product # MA5-51562) using a dilution of 1:400 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.

Phospho-HDAC4/HDAC5/HDAC9 (Ser246, Ser259, Ser220) Antibody in Western Blot (WB)

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产品信息

MA5-51562

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

免疫组化（石蜡） (IHC (P))

1:100-1:500

酶联免疫吸附实验 (ELISA)

1 µg/mL

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

8H4J9

抗原

A phospho synthetic peptide corresponding to residues surrounding S246&S259&S220 of Human HDAC4&HDAC5-S259&HDAC9.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.84 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

内含物

0.05% ProClin 300

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_3094411

靶标信息

Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins (1). Eight members of HDAC family have been identified in the past several years (2,3). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about twofold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns (3). These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Antigen NY-CO-9; DKFZp779K1053; HD4; HD5; HD7; HD7b; HD9; hdac-9; Histone deacetylase 4; histone deacetylase 4/5-related protein; Histone deacetylase 5; Histone deacetylase 7B; Histone deacetylase 9; histone deacetylase A; histone deacetylase mHDA1; Histone deacetylase-related protein; MEF-2 interacting transcription repressor (MITR) protein; MEF2-interacting transcription repressor MITR

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基因别名: 4932408F19Rik; AHO3; AI047285; AI426555; AV022454; BDMR; D030072B18Rik; HA6116; HD4; HD5; HD7; HD7B; HD9; HDAC; HDAC-4; HDAC-A; HDAC4; HDAC5; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDACA; HDRP; KIAA0288; KIAA0600; KIAA0744; mHDA1; MITR; mKIAA0600; mKIAA0744; NY-CO-9; RGD1310748; RGD1563092