Invitrogen

Phospho-HSL (Ser563) Polyclonal Antibody

Phospho-HSL (Ser563) Antibody in Western Blot (WB)

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Phospho-HSL (Ser563) Antibody (PA5-17488) in WB

Western blot analysis of Phospho-HSL pSer563 in extracts from differentiated 3T3-L1 cells treated with isoproterenol or lambda protein phosphatase using Phospho-HSL pSer563 polyclonal antibody (Product # PA5-17488).

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产品信息

PA5-17488

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

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产品规格

种属反应

Mouse

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic phosphopeptide corresponding to residues surrounding pSer552 of human HSL (equivalent to pSer563 of rat HSL)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

22.48 µg/mL

纯化类型

Antigen affinity chromatography

保存液

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

内含物

no preservative

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_10982460

产品详细信息

It is not recommended to aliquot this antibody.

This antibody is not cross-reactive with Ser565 phosphorylated HSL.

靶标信息

Hormone-sensitive lipase (HSL) is an intracellular neutral lipase found in a variety of tissues, but primarily in adipose and steroidogenic tissues. It hydrolyzes triglycerides and cholesteryl esters. It is the major enzyme responsible for the mobilization of free fatty acids from adopise tissue.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Lipopolysaccharide induces lipolysis and insulin resistance in adipose tissue from dairy cows.

Journal of dairy science

Chirivi M,Rendon CJ,Myers MN,Prom CM,Roy S,Sen A,Lock AL,Contreras GA

PA5-17488 was used in Western Blotting to provide evidence that during endotoxemia, dairy cows may be more susceptible to lipolysis dysregulation and loss of adipocyte sensitivity to the antilipolytic action of insulin.

Sat Jan 01 00:00:00 UTC 2022

Mutation of the novel acetylation site at K414R of BECN1 is involved in adipocyte differentiation and lipolysis.

Journal of cellular and molecular medicine

Li C,Xu J,Yu Q,Wang P,Dong B,Shen L,Wang Q,Li S,Yang Y,Deng Y

PA5-17488 was used in Western Blot to indicate the potential of BECN1 K414 as a key molecule and a drug target for regulating autophagy and lipid metabolism in adipocytes.

Thu Jul 01 00:00:00 UTC 2021

Antiobesity and antidiabetic effects of the dairy bacterium Propionibacterium freudenreichii MJ2 in high-fat diet-induced obese mice by modulating lipid metabolism.

Scientific reports

An M,Park YH,Lim YH

PA5-17488 was used in Western Blotting to investigate the antiobesity and antidiabetic effects of the dairy bacterium P. freudenreichii MJ2 isolated from raw milk using 3T3-L1 cells and high-fat diet (HFD)-induced obese mice.