Invitrogen

Phospho-HSL (Ser660) Polyclonal Antibody

Phospho-HSL (Ser660) Antibody in Western Blot (WB)

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Phospho-HSL (Ser660) Antibody (PA5-64494) in WB

Journal of sleep research 2021 - 5 FIGURE AT adrenergic stimulation following sleep restriction with and without exercise. Baseline, sleep restriction (SR) and sleep restriction with exercise (SREX) (a) ratio of phosphorylated hormone sensitive lipase (pHSL) to total HSL and (b) fatty acid synthase (FAS), with representative (c) protein blots. Unstimulated and stimulated secretion of (d) non-esterified fatty acids (NEFAs) and (e) glycerol

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产品信息

PA5-64494

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

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免疫组化（冰冻） (IHC (F))

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human HSL (Phospho-Ser660)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

AB_2662577

产品详细信息

Phospho-HSL (Ser660) Polyclonal Antibody detects endogenous levels of HSL only when phosphorylated at Ser660.

靶标信息

Hormone-sensitive lipase (HSL) is an intracellular neutral lipase found in a variety of tissues, but primarily in adipose and steroidogenic tissues. It hydrolyzes triglycerides and cholesteryl esters. It is the major enzyme responsible for the mobilization of free fatty acids from adopise tissue.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Deconstruction of a hypothalamic astrocyte-white adipocyte sympathetic axis that regulates lipolysis in mice.

Nature communications

Chen D,Qi Y,Zhang J,Yang Y

PA5-64494 was used in Western Blotting to reveal a central astrocyte-peripheral adipocyte axis modulating sympathetic drive to adipose tissues and adipocyte functions, one that might serve as a target for therapeutic intervention in the treatment of obesity.

Wed Dec 07 00:00:00 UTC 2022

Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes.

Nature communications

Zhao D,Wu K,Sharma S,Xing F,Wu SY,Tyagi A,Deshpande R,Singh R,Wabitsch M,Mo YY,Watabe K

PA5-64494 was used in Western Blot, Immunohistochemistry to reveal a mechanism of the disparity in breast cancer progression and suggest a potential utility of miR-1304-3p and the associated SNP as biomarkers for predicting the outcome of African American patients.

Wed Dec 14 00:00:00 UTC 2022

Modest sleep restriction does not influence steps, physical activity intensity or glucose tolerance in obese adults.

Journal of sleep research

Porter JW,Pettit-Mee RJ,Emerson TS,McCrae CS,Lastra G,Vieira-Potter VJ,Parks EJ,Kanaley JA

PA5-64494 was used in Western Blotting to determine the glucoregulatory effects of moderate sleep restriction (SR) (~6 h of sleep/night) in a free-living environment in overweight/obese individuals, the effects of SR on PA patterns and dietary composition, and the impact of SR on AT insulin sensitivity.

Wed Dec 01 00:00:00 UTC 2021

Modest sleep restriction does not influence steps, physical activity intensity or glucose tolerance in obese adults.

Journal of sleep research

Porter JW,Pettit-Mee RJ,Emerson TS,McCrae CS,Lastra G,Vieira-Potter VJ,Parks EJ,Kanaley JA

Wed Dec 01 00:00:00 UTC 2021

Higher lipid turnover and oxidation in cultured human myotubes from athletic versus sedentary young male subjects.

Scientific reports

Lund J,Helle SA,Li Y,Løvsletten NG,Stadheim HK,Jensen J,Kase ET,Thoresen GH,Rustan AC

PA5-64494 was used in Western Blotting to suggest that cultured myotubes retain some of the phenotypic traits of their donors.

Mon Dec 03 00:00:00 UTC 2018

生物信息学

蛋白别名: EC 3.1.1.79; hormone - sensitive lipase testicular isoform; Hormone-sensitive lipase; hormone-sensitive lipase testicular isoform; HSL; HSL antibody; lipase E; lipase, hormone-sensitive; LIPS; Monoacylglycerol lipase LIPE; REH; Retinyl ester hydrolase

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基因别名: 4933403G17Rik; AOMS4; FPLD6; HSL; LHS; LIPE

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UniProt ID: (Human) Q05469, (Rat) P15304, (Mouse) P54310

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Entrez Gene ID: (Human) 3991, (Rat) 25330, (Mouse) 16890

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