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Phospho-IFNAR1 (Ser535, Ser539) Antibody (PA1-4627) in WB
Western blot of IFNAR1 from HEK 293 cells transfected with Mock (Lane 1), IFNAR1 WT (Lane 2), and IFNAR1 (S535A, S539A) mutants (Lane 3) . Specific immunolabeling of bands from ~110 kDa to ~130 kDa corresponding to Phospho-IFNAR1, (Ser535, Ser539) polyclonal antibody (Product # PA1-4627) is shown in the first blot (left), as the immunolabeling is absent in IFNAR1 Ser535 and Ser539 mutants (Lane 3). The spec... View More
产品信息
PA1-4627
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser535/539 of human IFNAR1 conjugated to KLH
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2264542
产品详细信息
This antibody is predicted to react with bovine, canine, mouse, non-human primate and sheep based on 100% sequence homology.
It is specific for IFNAR1 protein phosphorylated at Ser535,539 in Western blots of human brain extracts.
靶标信息
Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron,2001, Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-& Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha-type antiviral protein; beta-type antiviral protein; CRF2-1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; H3K1; IFN R1; IFN-alpha/beta receptor 1; IFN-alpha/betaR1; IFN-alpha/betaRalpha; IFN-R-1; IFNalpha/beta R1; IFNalpha/beta-Ralpha; IFNalpha/betaR1; IFNR1; interferon (alpha, beta and omega) receptor 1; Interferon alpha/beta receptor 1; interferon receptor 1; interferon-alpha/beta receptor alpha chain; interferon-beta receptor 1; Type I interferon receptor 1
基因别名: AVP; IFN-alpha-REC; IFNAR; IFNAR1; IFNBR; IFRC
UniProt ID: (Human) P17181
Entrez Gene ID: (Human) 3454
JAK-STAT cascade
response to virus
response to lipopolysaccharide
positive regulation of interferon-beta production
positive regulation of interferon-gamma production
cellular response to interferon-alpha
T cell activation
type I interferon biosynthetic process
positive regulation of transcription, DNA-templated
positive regulation of interleukin-1 beta secretion
regulation of peptidyl-tyrosine phosphorylation
defense response to virus
type I interferon signaling pathway
regulation of type I interferon-mediated signaling pathway
