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产品信息
PA5-40296
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthesized peptide derived from human IP3R-I around the phosphorylation site of S1764.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2609014
产品详细信息
This antibody is predicted to react with human and mouse based on sequence homology.
靶标信息
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名:
Inositol 1,4,5 trisphosphate receptor; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor, type 1; Inositol 1,4,5-trisphosphate receptor; Inositol 1,4,5-trisphosphate receptor type 1; inositol 1,4,5-trisphosphate receptor, type 1; Inositol 1,4,5-trisphosphate-binding protein P400; Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1; InsP3R type I; insP3R1; InsP>3
基因别名: ACV; CLA4; D6Pas2; ENSMUSG00000072853; Gm10429; I145TR; InsP3R; INSP3R1; IP3R; IP3R1; Itpr-1; ITPR1; opt; P400; Pcd6; Pcp-1; Pcp1; PPP1R94; SCA15; SCA16; SCA29
UniProt ID: (Human) Q14643, (Mouse) P11881, (Rat) P29994
Entrez Gene ID: (Human) 3708, (Mouse) 16438, (Rat) 25262
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
protein binding
calcium ion transmembrane transporter activity
calcium-release channel activity
calcium channel inhibitor activity
phosphatidylinositol binding
ion channel activity
calcium channel activity
protein C-terminus binding
protein phosphatase binding
protein complex binding
ligand-gated ion channel
response to hypoxia
calcium ion transport
signal transduction
post-embryonic development
regulation of autophagy
platelet activation
endoplasmic reticulum calcium ion homeostasis
epithelial fluid transport
inositol phosphate-mediated signaling
regulation of insulin secretion
negative regulation of calcium-mediated signaling
voluntary musculoskeletal movement
release of sequestered calcium ion into cytosol
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
regulation of cardiac conduction
transport
ion transport
apoptotic process
positive regulation of cytosolic calcium ion concentration
positive regulation of calcium ion transport
transmembrane transport
calcium ion transmembrane transport
cellular response to cAMP
negative regulation of neuron death
cellular response to hypoxia
