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Phospho-L-Plastin (Ser5) Antibody (PA5-105825) in ICC/IF
Immunofluorescent analysis of Phospho-L-Plastin (Ser5) in HeLa cells(4h of LPS treatment). Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Phospho-L-Plastin (Ser5) polyclonal antibody (Product # PA5-105825) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluo... View More
产品信息
PA5-105825
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human LCP1(Accession P13796), corresponding to amino acid residues around phosphorylated Ser5.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2817224
产品详细信息
Antibody detects endogenous levels of Plastin L only when phosphorylated at Ser5.
靶标信息
L-plastin is a leukocyte specific actin bundling protein from fimbrin family of proteins. It has two actin-binding domains and two EF hand type calcium-binding domains. It gets phosphorylated on the serine residue in its headpiece region in response to a variety of inflammatory stimuli. It is hypothesized that L-plastin may play a role in regulating integrin mediated adhesion in leukocytes. L-plastin is expressed in majority of human cancer cell lines derived from solid tumors. Its expression is positively upregulated by testosterones in androgen receptor positive prostrate and breast cancer cells through three androgen receptor binding elements located in the upstream region of the gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 65 kDa macrophage protein; bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin)); DKFZp781A23186; epididymis secretory protein Li 37; FLJ25423; FLJ26114; FLJ39956; L-fimbrin; L-plastin; L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (PP65); L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P); LC64P; LCP-1; Lymphocyte cytosolic protein 1; lymphocyte cytosolic protein 1 (L-plastin); Lymphocyte cytosolic protein-1 (plasmin); plastin 2; plastin 2, L; Plastin-2; pp65
基因别名: AW536232; CP64; D14Ertd310e; HEL-S-37; L-PLASTIN; LC64P; LCP-1; LCP1; LPL; PLS2; pp65
UniProt ID: (Human) P13796, (Mouse) Q61233
Entrez Gene ID: (Human) 3936, (Mouse) 18826, (Rat) 306071
T cell activation involved in immune response
protein kinase A signaling
cell migration
extracellular matrix disassembly
organ regeneration
regulation of intracellular protein transport
wound healing, spreading of cells
actin filament bundle assembly
positive regulation of podosome assembly
response to wounding
